MS432 [Ligand Id: 10563] activity data from GtoPdb

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  • mitogen-activated protein kinase kinase 1 in Human [GtoPdb: 2062] [UniProtKB: Q02750]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 mitogen-activated protein kinase kinase 1 Human
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  • mitogen-activated protein kinase kinase 2 in Human [GtoPdb: 2063] [UniProtKB: P36507]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 mitogen-activated protein kinase kinase 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase kinase 1 in Human [GtoPdb: 2062] [UniProtKB: Q02750]
GtoPdb Determined in an in vitro biochemical assay, using a kinase-dead ERK mutant as the substrate for hMEK1. - 5.82 pIC50 1500 nM IC50 J Med Chem (2019) 62: 10897-10911 [PMID:31730343]
mitogen-activated protein kinase kinase 2 in Human [GtoPdb: 2063] [UniProtKB: P36507]
GtoPdb Determined in an in vitro biochemical assay, using a kinase-dead ERK mutant as the substrate for hMEK2. - 6.23 pIC50 590 nM IC50 J Med Chem (2019) 62: 10897-10911 [PMID:31730343]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.