isobutyric acid [Ligand Id: 1060] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL108778 (Isobutyric Acid)
  • FFA3 receptor in Human [GtoPdb: 227] [UniProtKB: O14843]
  • FFA3 receptor/Free fatty acid receptor 3 in Rat [ChEMBL: CHEMBL3886125] [GtoPdb: 227] [UniProtKB: B2GV46]
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  • FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
FFA3 receptor in Human [GtoPdb: 227] [UniProtKB: O14843]
GtoPdb - - 4.8 pEC50 - - - J Biol Chem (2003) 278: 11312-9 [PMID:12496283];
Proc Natl Acad Sci USA (2004) 101: 1045-50 [PMID:14722361]
FFA3 receptor/Free fatty acid receptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886125] [GtoPdb: 227] [UniProtKB: B2GV46]
ChEMBL Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay B 4.52 pEC50 30000 nM EC50 WO-2001061359-A2. Identification of modulators of GPR41 or GPR42 activity (2001)
FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552]
GtoPdb - - 3.8 pEC50 - - - J Biol Chem (2003) 278: 25481-9 [PMID:12711604]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]