rodatristat [Ligand Id: 10647] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4104957 (KAR-5417, KAR5417, Rodatristat, RVT-1201/014) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| L-Tryptophan hydroxylase 1/Tryptophan 5-hydroxylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5689] [GtoPdb: 1241] [UniProtKB: P17752] | ||||||||
| GtoPdb | - | - | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 413-419 [PMID:28041831] |
| ChEMBL | Inhibition of TPH1 (unknown origin) | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 413-419 [PMID:28041831] |
| L-Tryptophan hydroxylase 2 in Human [GtoPdb: 1242] [UniProtKB: Q8IWU9] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 413-419 [PMID:28041831] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
