samidorphan [Ligand Id: 10651] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL426084 (Alks-33, ALKS 33, ALKS-33, ALKS-5461 COMPONENT SAMIDORPHAN, RDC-0313, RDC-0313-00, Samidorphan) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Binding affinity against Opioid receptor delta 1 expressed in CHO cells using [3H]Naltrindole as radioligand | B | 8.59 | pKi | 2.6 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-2110 [PMID:15808478] |
| GtoPdb | - | - | 8.59 | pKi | 2.6 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-10 [PMID:15808478] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Binding affinity against Opioid receptor kappa 1 expressed in CHO cells using [3H]U-69593 as radioligand | B | 9.64 | pKi | 0.23 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-2110 [PMID:15808478] |
| GtoPdb | - | - | 9.64 | pKi | 0.23 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-10 [PMID:15808478] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| GtoPdb | - | - | 10.28 | pKi | 0.05 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-10 [PMID:15808478] |
| ChEMBL | Binding affinity against Opioid receptor mu 1 expressed in CHO cells using [3H]DAMGO as radioligand | B | 10.28 | pKi | 0.05 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-2110 [PMID:15808478] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
