samidorphan [Ligand Id: 10651] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL426084 (Alks-33, ALKS 33, ALKS-33, ALKS-5461 COMPONENT SAMIDORPHAN, RDC-0313, RDC-0313-00, Samidorphan) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Binding affinity against Opioid receptor delta 1 expressed in CHO cells using [3H]Naltrindole as radioligand | B | 8.59 | pKi | 2.6 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-2110 [PMID:15808478] |
| GtoPdb | - | - | 8.59 | pKi | 2.6 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-10 [PMID:15808478] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Binding affinity against Opioid receptor kappa 1 expressed in CHO cells using [3H]U-69593 as radioligand | B | 9.64 | pKi | 0.23 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-2110 [PMID:15808478] |
| GtoPdb | - | - | 9.64 | pKi | 0.23 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-10 [PMID:15808478] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| GtoPdb | - | - | 10.28 | pKi | 0.05 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-10 [PMID:15808478] |
| ChEMBL | Binding affinity against Opioid receptor mu 1 expressed in CHO cells using [3H]DAMGO as radioligand | B | 10.28 | pKi | 0.05 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2107-2110 [PMID:15808478] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
