CGP 35348 [Ligand Id: 1069] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL40157 (CGP-35348)
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  • GABAB receptor in Human [GtoPdb: 242]
  • GABAB receptor in Rat [GtoPdb: 242]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GABAB2/GABAB1/GABA B receptor in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111474] [GtoPdb: 241240] [UniProtKB: O88871Q9Z0U4]
GtoPdb - - 4.8 pIC50 - - - Nature (1997) 386: 239-46 [PMID:9069281];
J Med Chem (1995) 38: 3313-31 [PMID:7650685]
ChEMBL In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranes B 5.6 pIC50 2500 nM IC50 Bioorg. Med. Chem. Lett. (1993) 3: 515-518
GABAB1/GABA-B receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2753] [GtoPdb: 240] [UniProtKB: Q9Z0U4]
ChEMBL Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex. B 4.57 pIC50 27000 nM IC50 J. Med. Chem. (1995) 38: 3313-3331 [PMID:7650685]
GtoPdb - - 4.8 pIC50 - - - Nature (1997) 386: 239-46 [PMID:9069281];
J Med Chem (1995) 38: 3313-31 [PMID:7650685]
GABAB receptor in Human [GtoPdb: 242]
GtoPdb - - 4.4 pKi - - - Br J Pharmacol (2000) 131: 1050-4 [PMID:11082110]
GABAB receptor in Rat [GtoPdb: 242]
GtoPdb - - 5.4 pIC50 - - - Pharmacol Rev (2002) 54: 247-64 [PMID:12037141]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]