compound 18 [PMID: 24119557] [Ligand Id: 10695] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2440750
  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
  • This target only has 0 pki data point
1 CHEMBL2440750_lig_chart_1 Rho-associated protein kinase 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
GtoPdb - - 8.29 pIC50 5.1 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 6442-6 [PMID:24119557]
ChEMBL Inhibition of ROCK2 (unknown origin) using long S6 kinase peptide as substrate by radiometric assay B 8.29 pIC50 5.1 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 6442-6446 [PMID:24119557]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]