compound 15a [PMID: 32069401] [Ligand Id: 10702] activity data from GtoPdb

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  • mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta in Human [GtoPdb: 2155] [UniProtKB: O00329]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma in Human [GtoPdb: 2156] [UniProtKB: P48736]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
GtoPdb - - 7.68 pIC50 21 nM IC50 J Med Chem (2020) 63: 3028-3046 [PMID:32069401]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
GtoPdb - - 9.7 pIC50 0.2 nM IC50 J Med Chem (2020) 63: 3028-3046 [PMID:32069401]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
GtoPdb - - 9.24 pIC50 0.58 nM IC50 J Med Chem (2020) 63: 3028-3046 [PMID:32069401]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta in Human [GtoPdb: 2155] [UniProtKB: O00329]
GtoPdb - - 9.3 pIC50 0.5 nM IC50 J Med Chem (2020) 63: 3028-3046 [PMID:32069401]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma in Human [GtoPdb: 2156] [UniProtKB: P48736]
GtoPdb - - 8.92 pIC50 1.2 nM IC50 J Med Chem (2020) 63: 3028-3046 [PMID:32069401]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.