avibactam [Ligand Id: 10761] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1689063 (Avibactam, Nxl-104, NXL104, Nxl-104 free acid)
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  • Beta-lactamase in Enterobacter cloacae [ChEMBL: CHEMBL2725] [UniProtKB: P05364]
  • Beta-lactamase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) [ChEMBL: CHEMBL5031] [UniProtKB: P24735]
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  • Class A carbapenemase KPC-2 in Escherichia coli [ChEMBL: CHEMBL5437] [UniProtKB: A8DS27]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Bacterial beta-lactamase TEM in Bacteria (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2364670] [UniProtKB: P62593]
ChEMBL Inhibition of bacterial Beta-lactamase TEM-1 (24 - 286) (unknown origin) expressed in Escherichia coli Transetta (DE3) B 8.72 pIC50 1.9 nM IC50 Bioorg Med Chem Lett (2021) 41: 127956-127956 [PMID:33744439]
Beta-lactamase in Enterobacter cloacae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2725] [UniProtKB: P05364]
ChEMBL Inhibition of Enterobacter cloacae beta-lactamase P99 after 5 seconds incubation with nitrocefin substrate by spectrophotometry B 5.11 pKi 7700 nM Ki Antimicrob Agents Chemother (2010) 54: 5132-5138 [PMID:20921316]
ChEMBL Inhibition of Enterobacter cloacae beta-lactamase P99 assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubation B 7 pIC50 100 nM IC50 Antimicrob Agents Chemother (2010) 54: 5132-5138 [PMID:20921316]
Beta-lactamase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5031] [UniProtKB: P24735]
ChEMBL Inhibition of Pseudomonas aeruginosa beta-lactamase AmpC assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubation B 6.89 pIC50 128 nM IC50 Antimicrob Agents Chemother (2010) 54: 5132-5138 [PMID:20921316]
Beta-lactamase OXA-23 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3885669] [UniProtKB: Q9L4P2]
ChEMBL Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 secs for 10 mins by spectrophotometrically analysis B 5.77 pKi 1700 nM Ki J Med Chem (2020) 63: 7491-7507 [PMID:32150407]
BlaVIM-1 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255155] [UniProtKB: Q8GDC1]
ChEMBL Inhibition of recombinant Escherichia coli VIM-1 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 secs for 10 mins by spectrophotometrically analysis B 4.4 pKi >40000 nM Ki J Med Chem (2020) 63: 7491-7507 [PMID:32150407]
Class A carbapenemase KPC-2 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5437] [UniProtKB: A8DS27]
ChEMBL Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured every 10 secs for 10 mins by spectrophotometric analysis B 7.96 pKi 11 nM Ki J Med Chem (2020) 63: 7491-7507 [PMID:32150407]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]