avibactam [Ligand Id: 10761] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1689063 (Avibactam, NXL104, Nxl-104)
  • Beta-lactamase in Enterobacter cloacae [ChEMBL: CHEMBL2725] [UniProtKB: P05364]
  • Beta-lactamase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) [ChEMBL: CHEMBL5031] [UniProtKB: P24735]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-lactamase in Enterobacter cloacae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2725] [UniProtKB: P05364]
ChEMBL Inhibition of Enterobacter cloacae beta-lactamase P99 after 5 seconds incubation with nitrocefin substrate by spectrophotometry B 5.11 pKi 7700 nM Ki Antimicrob. Agents Chemother. (2010) 54: 5132-5138 [PMID:20921316]
ChEMBL Inhibition of Enterobacter cloacae beta-lactamase P99 assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubation B 7 pIC50 100 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 5132-5138 [PMID:20921316]
Beta-lactamase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5031] [UniProtKB: P24735]
ChEMBL Inhibition of Pseudomonas aeruginosa beta-lactamase AmpC assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubation B 6.89 pIC50 128 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 5132-5138 [PMID:20921316]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]