avibactam [Ligand Id: 10761] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1689063 (Avibactam, Nxl-104, NXL104, Nxl-104 free acid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Bacterial beta-lactamase TEM in Bacteria (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2364670] [UniProtKB: P62593] | ||||||||
| ChEMBL | Inhibition of bacterial Beta-lactamase TEM-1 (24 - 286) (unknown origin) expressed in Escherichia coli Transetta (DE3) | B | 8.72 | pIC50 | 1.9 | nM | IC50 | Bioorg Med Chem Lett (2021) 41: 127956-127956 [PMID:33744439] |
| Beta-lactamase in Enterobacter cloacae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2725] [UniProtKB: P05364] | ||||||||
| ChEMBL | Inhibition of Enterobacter cloacae beta-lactamase P99 after 5 seconds incubation with nitrocefin substrate by spectrophotometry | B | 5.11 | pKi | 7700 | nM | Ki | Antimicrob Agents Chemother (2010) 54: 5132-5138 [PMID:20921316] |
| ChEMBL | Inhibition of Enterobacter cloacae beta-lactamase P99 assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubation | B | 7 | pIC50 | 100 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 5132-5138 [PMID:20921316] |
| Beta-lactamase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5031] [UniProtKB: P24735] | ||||||||
| ChEMBL | Inhibition of Pseudomonas aeruginosa beta-lactamase AmpC assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubation | B | 6.89 | pIC50 | 128 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 5132-5138 [PMID:20921316] |
| Beta-lactamase OXA-23 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3885669] [UniProtKB: Q9L4P2] | ||||||||
| ChEMBL | Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 secs for 10 mins by spectrophotometrically analysis | B | 5.77 | pKi | 1700 | nM | Ki | J Med Chem (2020) 63: 7491-7507 [PMID:32150407] |
| BlaVIM-1 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255155] [UniProtKB: Q8GDC1] | ||||||||
| ChEMBL | Inhibition of recombinant Escherichia coli VIM-1 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 secs for 10 mins by spectrophotometrically analysis | B | 4.4 | pKi | >40000 | nM | Ki | J Med Chem (2020) 63: 7491-7507 [PMID:32150407] |
| Class A carbapenemase KPC-2 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5437] [UniProtKB: A8DS27] | ||||||||
| ChEMBL | Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured every 10 secs for 10 mins by spectrophotometric analysis | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (2020) 63: 7491-7507 [PMID:32150407] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
