aztreonam [Ligand Id: 10763] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL158 (Cayston, NSC-646279, Aztreonam, SO 26776, SQ 26776, Azactam, SQ-26776)
  • ADC-11 in Acinetobacter baumannii [ChEMBL: CHEMBL1667701] [UniProtKB: D6NSM8]
  • This target only has 1 pki data point
  • 5.52
1 CHEMBL158_lig_chart_1 ADC-11 Acinetobacter baumannii
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  • AmpC in Escherichia coli [ChEMBL: CHEMBL1255151] [UniProtKB: Q83TT7]
  • This target only has 0 pki data point
  • 0
2 CHEMBL158_lig_chart_2 AmpC Escherichia coli
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  • Beta-lactamase ACC-4 in Escherichia coli [ChEMBL: CHEMBL5305] [UniProtKB: A4ZYU9]
  • This target only has 0 pki data point
  • 0
3 CHEMBL158_lig_chart_3 Beta-lactamase ACC-4 Escherichia coli
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  • Beta-lactamase ADC-33 in Acinetobacter baumannii [ChEMBL: CHEMBL1667700] [UniProtKB: B2ZTR6]
  • This target only has 1 pki data point
  • 8.15
4 CHEMBL158_lig_chart_4 Beta-lactamase ADC-33 Acinetobacter baumannii
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  • Class C beta-lactamase CMY-36 in Klebsiella pneumoniae [ChEMBL: CHEMBL1641338] [UniProtKB: Q48435]
  • This target only has 0 pki data point
  • 0
5 CHEMBL158_lig_chart_5 Class C beta-lactamase CMY-36 Klebsiella pneumoniae
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  • Efflux transporter in Salmonella newport [ChEMBL: CHEMBL1641337] [UniProtKB: Q3S5C3]
  • This target only has 0 pki data point
  • 0
6 CHEMBL158_lig_chart_6 Efflux transporter Salmonella newport
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  • Penicillin-binding protein 1A in Pseudomonas aeruginosa PAO1 [ChEMBL: CHEMBL3259512] [UniProtKB: Q07806]
  • This target only has 0 pki data point
  • 0
7 CHEMBL158_lig_chart_7 Penicillin-binding protein 1A Pseudomonas aeruginosa PAO1
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  • PER-2 beta-lactamase in Citrobacter freundii [ChEMBL: CHEMBL5303] [UniProtKB: A2RP81]
  • This target only has 1 pki data point
  • 5.7
8 CHEMBL158_lig_chart_8 PER-2 beta-lactamase Citrobacter freundii
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ADC-11 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667701] [UniProtKB: D6NSM8]
ChEMBL Activity of Acinetobacter baumannii ADC-11 beta-lactamase B 5.52 pKi 3000 nM Ki Antimicrob. Agents Chemother. (2010) 54: 3484-3488 [PMID:20547808]
AmpC in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255151] [UniProtKB: Q83TT7]
ChEMBL Inhibition of Escherichia coli ATCC 25922 AmpC B 7.22 pIC50 60 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 2291-2302 [PMID:20308379]
Beta-lactamase ACC-4 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5305] [UniProtKB: A4ZYU9]
ChEMBL Inhibition of Escherichia coli beta-lactamase ACC4 B 7.49 pIC50 32 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 3763-3767 [PMID:17664321]
Beta-lactamase ADC-33 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667700] [UniProtKB: B2ZTR6]
ChEMBL Activity of Acinetobacter baumannii ADC-33 beta-lactamase B 8.15 pKi 7 nM Ki Antimicrob. Agents Chemother. (2010) 54: 3484-3488 [PMID:20547808]
Class C beta-lactamase CMY-36 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641338] [UniProtKB: Q48435]
ChEMBL Inhibition of Klebsiella pneumoniae HP205 cephalosporinase CMY-36 by UV spectrophotometer in presence of 100 uM of cephalothin B 8.22 pIC50 6 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1256-1259 [PMID:19104021]
Efflux transporter in Salmonella newport (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641337] [UniProtKB: Q3S5C3]
ChEMBL Inhibition of Salmonella enterica serotype Newport AM17274 cephalosporinase CMY-31 by UV spectrophotometer in presence of 100 uM of cephalothin B 8.22 pIC50 6 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1256-1259 [PMID:19104021]
Penicillin-binding protein 1A in Pseudomonas aeruginosa PAO1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259512] [UniProtKB: Q07806]
ChEMBL Displacement of fluorescent Bocillin FL from N-terminal His tagged Pseudomonas aeruginosa PAO1 PBP1a (residues 36 to 822) expressed in Escherichia coli BL21 (Gold cells) B 5.48 pIC50 3340 nM IC50 J. Med. Chem. (2014) 57: 3845-3855 [PMID:24694215]
PER-2 beta-lactamase in Citrobacter freundii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5303] [UniProtKB: A2RP81]
ChEMBL Inhibition of Citrobacter freundii PER2 beta lactamase B 5.7 pKi 2000 nM Ki Antimicrob. Agents Chemother. (2007) 51: 2359-2365 [PMID:17438050]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]