aztreonam [Ligand Id: 10763] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL158 (Azactam, Azonam, Aztreon, Aztreonam, Cayston, Nebactam, NSC-646279, NSC-758913, Primbactam, SO 26776, SQ 26776, SQ-26776) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADC-11 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667701] [UniProtKB: D6NSM8] | ||||||||
| ChEMBL | Activity of Acinetobacter baumannii ADC-11 beta-lactamase | B | 5.52 | pKi | 3000 | nM | Ki | Antimicrob Agents Chemother (2010) 54: 3484-3488 [PMID:20547808] |
| AmpC in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255151] [UniProtKB: Q83TT7] | ||||||||
| ChEMBL | Inhibition of Escherichia coli ATCC 25922 AmpC | B | 7.22 | pIC50 | 60 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 2291-2302 [PMID:20308379] |
| Beta-lactamase ACC-4 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5305] [UniProtKB: A4ZYU9] | ||||||||
| ChEMBL | Inhibition of Escherichia coli beta-lactamase ACC4 | B | 7.49 | pIC50 | 32 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3763-3767 [PMID:17664321] |
| Beta-lactamase ADC-33 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667700] [UniProtKB: B2ZTR6] | ||||||||
| ChEMBL | Activity of Acinetobacter baumannii ADC-33 beta-lactamase | B | 8.15 | pKi | 7 | nM | Ki | Antimicrob Agents Chemother (2010) 54: 3484-3488 [PMID:20547808] |
| Class C beta-lactamase CMY-36 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641338] [UniProtKB: Q48435] | ||||||||
| ChEMBL | Inhibition of Klebsiella pneumoniae HP205 cephalosporinase CMY-36 by UV spectrophotometer in presence of 100 uM of cephalothin | B | 8.22 | pIC50 | 6 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 1256-1259 [PMID:19104021] |
| Efflux transporter in Salmonella newport (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641337] [UniProtKB: Q3S5C3] | ||||||||
| ChEMBL | Inhibition of Salmonella enterica serotype Newport AM17274 cephalosporinase CMY-31 by UV spectrophotometer in presence of 100 uM of cephalothin | B | 8.22 | pIC50 | 6 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 1256-1259 [PMID:19104021] |
| Penicillin-binding protein 1A in Pseudomonas aeruginosa PAO1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259512] [UniProtKB: Q07806] | ||||||||
| ChEMBL | Displacement of fluorescent Bocillin FL from N-terminal His tagged Pseudomonas aeruginosa PAO1 PBP1a (residues 36 to 822) expressed in Escherichia coli BL21 (Gold cells) | B | 5.48 | pIC50 | 3340 | nM | IC50 | J Med Chem (2014) 57: 3845-3855 [PMID:24694215] |
| PER-2 beta-lactamase in Citrobacter freundii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5303] [UniProtKB: A2RP81] | ||||||||
| ChEMBL | Inhibition of Citrobacter freundii PER2 beta lactamase | B | 5.7 | pKi | 2000 | nM | Ki | Antimicrob Agents Chemother (2007) 51: 2359-2365 [PMID:17438050] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
