aztreonam [Ligand Id: 10763] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL158 (Azactam, Azonam, Aztreon, Aztreonam, Cayston, Nebactam, NSC-646279, NSC-758913, Primbactam, SO 26776, SQ 26776, SQ-26776) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADC-11 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667701] [UniProtKB: D6NSM8] | ||||||||
| ChEMBL | Activity of Acinetobacter baumannii ADC-11 beta-lactamase | B | 5.52 | pKi | 3000 | nM | Ki | Antimicrob Agents Chemother (2010) 54: 3484-3488 [PMID:20547808] |
| AmpC in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255151] [UniProtKB: Q83TT7] | ||||||||
| ChEMBL | Inhibition of Escherichia coli ATCC 25922 AmpC | B | 7.22 | pIC50 | 60 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 2291-2302 [PMID:20308379] |
| Beta-lactamase ACC-4 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5305] [UniProtKB: A4ZYU9] | ||||||||
| ChEMBL | Inhibition of Escherichia coli beta-lactamase ACC4 | B | 7.49 | pIC50 | 32 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3763-3767 [PMID:17664321] |
| Beta-lactamase ADC-33 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667700] [UniProtKB: B2ZTR6] | ||||||||
| ChEMBL | Activity of Acinetobacter baumannii ADC-33 beta-lactamase | B | 8.15 | pKi | 7 | nM | Ki | Antimicrob Agents Chemother (2010) 54: 3484-3488 [PMID:20547808] |
| Class C beta-lactamase CMY-36 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641338] [UniProtKB: Q48435] | ||||||||
| ChEMBL | Inhibition of Klebsiella pneumoniae HP205 cephalosporinase CMY-36 by UV spectrophotometer in presence of 100 uM of cephalothin | B | 8.22 | pIC50 | 6 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 1256-1259 [PMID:19104021] |
| Efflux transporter in Salmonella newport (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641337] [UniProtKB: Q3S5C3] | ||||||||
| ChEMBL | Inhibition of Salmonella enterica serotype Newport AM17274 cephalosporinase CMY-31 by UV spectrophotometer in presence of 100 uM of cephalothin | B | 8.22 | pIC50 | 6 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 1256-1259 [PMID:19104021] |
| Penicillin-binding protein 1A in Pseudomonas aeruginosa PAO1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259512] [UniProtKB: Q07806] | ||||||||
| ChEMBL | Displacement of fluorescent Bocillin FL from N-terminal His tagged Pseudomonas aeruginosa PAO1 PBP1a (residues 36 to 822) expressed in Escherichia coli BL21 (Gold cells) | B | 5.48 | pIC50 | 3340 | nM | IC50 | J Med Chem (2014) 57: 3845-3855 [PMID:24694215] |
| PER-2 beta-lactamase in Citrobacter freundii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5303] [UniProtKB: A2RP81] | ||||||||
| ChEMBL | Inhibition of Citrobacter freundii PER2 beta lactamase | B | 5.7 | pKi | 2000 | nM | Ki | Antimicrob Agents Chemother (2007) 51: 2359-2365 [PMID:17438050] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
