aztreonam [Ligand Id: 10763] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL158 (Azactam, Azonam, Aztreon, Aztreonam, Cayston, Nebactam, NSC-646279, NSC-758913, Primbactam, SO 26776, SQ 26776, SQ-26776)
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Beta-lactamase ACC-4 in Escherichia coli [ChEMBL: CHEMBL5305] [UniProtKB: A4ZYU9]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Class C beta-lactamase CMY-36 in Klebsiella pneumoniae [ChEMBL: CHEMBL1641338] [UniProtKB: Q48435]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Penicillin-binding protein 1A in Pseudomonas aeruginosa PAO1 [ChEMBL: CHEMBL3259512] [UniProtKB: Q07806]
There should be some charts here, you may need to enable JavaScript!
  • PER-2 beta-lactamase in Citrobacter freundii [ChEMBL: CHEMBL5303] [UniProtKB: A2RP81]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ADC-11 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667701] [UniProtKB: D6NSM8]
ChEMBL Activity of Acinetobacter baumannii ADC-11 beta-lactamase B 5.52 pKi 3000 nM Ki Antimicrob Agents Chemother (2010) 54: 3484-3488 [PMID:20547808]
AmpC in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255151] [UniProtKB: Q83TT7]
ChEMBL Inhibition of Escherichia coli ATCC 25922 AmpC B 7.22 pIC50 60 nM IC50 Antimicrob Agents Chemother (2010) 54: 2291-2302 [PMID:20308379]
Beta-lactamase ACC-4 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5305] [UniProtKB: A4ZYU9]
ChEMBL Inhibition of Escherichia coli beta-lactamase ACC4 B 7.49 pIC50 32 nM IC50 Antimicrob Agents Chemother (2007) 51: 3763-3767 [PMID:17664321]
Beta-lactamase ADC-33 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667700] [UniProtKB: B2ZTR6]
ChEMBL Activity of Acinetobacter baumannii ADC-33 beta-lactamase B 8.15 pKi 7 nM Ki Antimicrob Agents Chemother (2010) 54: 3484-3488 [PMID:20547808]
Class C beta-lactamase CMY-36 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641338] [UniProtKB: Q48435]
ChEMBL Inhibition of Klebsiella pneumoniae HP205 cephalosporinase CMY-36 by UV spectrophotometer in presence of 100 uM of cephalothin B 8.22 pIC50 6 nM IC50 Antimicrob Agents Chemother (2009) 53: 1256-1259 [PMID:19104021]
Efflux transporter in Salmonella newport (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641337] [UniProtKB: Q3S5C3]
ChEMBL Inhibition of Salmonella enterica serotype Newport AM17274 cephalosporinase CMY-31 by UV spectrophotometer in presence of 100 uM of cephalothin B 8.22 pIC50 6 nM IC50 Antimicrob Agents Chemother (2009) 53: 1256-1259 [PMID:19104021]
Penicillin-binding protein 1A in Pseudomonas aeruginosa PAO1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259512] [UniProtKB: Q07806]
ChEMBL Displacement of fluorescent Bocillin FL from N-terminal His tagged Pseudomonas aeruginosa PAO1 PBP1a (residues 36 to 822) expressed in Escherichia coli BL21 (Gold cells) B 5.48 pIC50 3340 nM IC50 J Med Chem (2014) 57: 3845-3855 [PMID:24694215]
PER-2 beta-lactamase in Citrobacter freundii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5303] [UniProtKB: A2RP81]
ChEMBL Inhibition of Citrobacter freundii PER2 beta lactamase B 5.7 pKi 2000 nM Ki Antimicrob Agents Chemother (2007) 51: 2359-2365 [PMID:17438050]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]