ceftobiprole [Ligand Id: 10787] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL520642 (Zeftera, Zevtera, RO-639141, Ceftobiprole, BAL-9141000, BAL-9141-000, RO-63-9141, BAL9141-000, RO 63-9141)
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MecA in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6187] [UniProtKB: Q7DHH4]
ChEMBL Binding affinity to Staphylococcus aureus ATCC 433000 PBP2a by Western blotting at pH 5.5 in presence of 100 uM Bocillin FL B 5.13 pIC50 7400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2289-2297 [PMID:19289525]
ChEMBL Inhibition of methicillin-resistant Staphylococcus aureus COL PBP2a by competitive assay B 5.49 pIC50 3200 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 2709-2717 [PMID:18505853]
ChEMBL Binding affinity to Staphylococcus aureus ATCC 433000 PBP2a by Western blotting at pH 7.4 in presence of 100 uM Bocillin FL B 5.72 pIC50 1900 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2289-2297 [PMID:19289525]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]