imipenem [Ligand Id: 10821] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL148 (MK-0787, Imipenem)
  • Beta-lactamase GES-13 in Pseudomonas aeruginosa [ChEMBL: CHEMBL1250341] [UniProtKB: D1MIX9]
  • This target only has 0 pki data point
  • 0
1 CHEMBL148_lig_chart_1 Beta-lactamase GES-13 Pseudomonas aeruginosa
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  • PER-2 beta-lactamase in Citrobacter freundii [ChEMBL: CHEMBL5303] [UniProtKB: A2RP81]
  • This target only has 1 pki data point
  • 7.22
2 CHEMBL148_lig_chart_2 PER-2 beta-lactamase Citrobacter freundii
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-lactamase GES-13 in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250341] [UniProtKB: D1MIX9]
ChEMBL Inhibition of Pseudomonas aeruginosa GES-13 beta lactamase B 6.82 pIC50 150 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1331-1333 [PMID:20065056]
PER-2 beta-lactamase in Citrobacter freundii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5303] [UniProtKB: A2RP81]
ChEMBL Inhibition of Citrobacter freundii PER2 beta lactamase B 7.22 pKi 60 nM Ki Antimicrob. Agents Chemother. (2007) 51: 2359-2365 [PMID:17438050]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]