Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL3112741 |
---|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Beta-lactamase in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641350] [UniProtKB: Q8RL90] | ||||||||
ChEMBL | Spectrophotometric Assay: Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay. | B | 6.33 | pIC50 | 465 | nM | IC50 | US-8487093-B2. Œ=-lactamase inhibitors (2013) |
Beta-lactamase in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075159] [UniProtKB: Q8RLA6] | ||||||||
ChEMBL | Inhibition of beta-lactamase Oxa40 in Acinetobacter baumannii assessed as inhibition of hydrolysis of nitrocefin | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2014) 24: 780-785 [PMID:24433862] |
Beta-lactamase in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641358] [UniProtKB: Q93LQ9] | ||||||||
ChEMBL | Spectrophotometric Assay: Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay. | B | 6.68 | pIC50 | 210 | nM | IC50 | US-8487093-B2. Œ=-lactamase inhibitors (2013) |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]