relebactam [Ligand Id: 10852] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3112741
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-lactamase in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641350] [UniProtKB: Q8RL90]
ChEMBL Spectrophotometric Assay: Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay. B 6.33 pIC50 465 nM IC50 US-8487093-B2. Œ=-lactamase inhibitors (2013)
Beta-lactamase in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075159] [UniProtKB: Q8RLA6]
ChEMBL Inhibition of beta-lactamase Oxa40 in Acinetobacter baumannii assessed as inhibition of hydrolysis of nitrocefin B 4.3 pIC50 >50000 nM IC50 Bioorg Med Chem Lett (2014) 24: 780-785 [PMID:24433862]
Beta-lactamase in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641358] [UniProtKB: Q93LQ9]
ChEMBL Spectrophotometric Assay: Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay. B 6.68 pIC50 210 nM IC50 US-8487093-B2. Œ=-lactamase inhibitors (2013)

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]