relebactam [Ligand Id: 10852] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3112741
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-lactamase in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641350] [UniProtKB: Q8RL90]
ChEMBL Spectrophotometric Assay: Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay. B 6.33 pIC50 465 nM IC50 US-8487093-B2. Œ=-lactamase inhibitors (2013)
Beta-lactamase in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075159] [UniProtKB: Q8RLA6]
ChEMBL Inhibition of beta-lactamase Oxa40 in Acinetobacter baumannii assessed as inhibition of hydrolysis of nitrocefin B 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 780-785 [PMID:24433862]
Beta-lactamase in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641358] [UniProtKB: Q93LQ9]
ChEMBL Spectrophotometric Assay: Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay. B 6.68 pIC50 210 nM IC50 US-8487093-B2. Œ=-lactamase inhibitors (2013)

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]