tedizolid [Ligand Id: 10865] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1257051 (Sivextro, Tedizolid, Torezolid, TR-700)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL Inhibition of MAO-A (unknown origin) by luciferase reporter gene assay B 5.7 pKi <2000 nM Ki Bioorg Med Chem (2013) 21: 577-591 [PMID:23273607]
ChEMBL Reversible inhibition of human MAO-A B 5.06 pIC50 8700 nM IC50 Eur J Med Chem (2015) 106: 120-131 [PMID:26536532]
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL Reversible inhibition of human MAO-B B 5.24 pIC50 5700 nM IC50 Eur J Med Chem (2015) 106: 120-131 [PMID:26536532]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]