asunaprevir [Ligand Id: 10882] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2105735 (Asunaprevir, BMS 650032, BMS-650032, Sunvepra)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Hepatitis C virus serine protease, NS3/NS4A in Hepatitis C virus (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095231] [UniProtKB: A3EZI9, D2K2A8]
ChEMBL Inhibition of recombinant full length HCV genotype 1a NS3/4A protease (1027 to 1711 residues) expressed in Escherichia coli strain BL21 (DE3) using RET S1 as substrate incubated for 1 min followed by substrate addition measured after 15 mins by FRET assay B 9 pIC50 1 nM IC50 ACS Med Chem Lett (2018) 9: 143-148 [PMID:29456803]
ChEMBL Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET peptide substrate by FRET assay B 9 pIC50 1 nM IC50 Bioorg Med Chem Lett (2018) 28: 1853-1859 [PMID:29650290]
NS3 in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293269] [UniProtKB: A3EZJ3]
ChEMBL Inhibition of HCV genotype 1a H77 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luciferase reporter gene assay B 8.4 pEC50 4 nM EC50 Bioorg Med Chem Lett (2018) 28: 43-48 [PMID:29162454]
ChEMBL Inhibition of HCV genotype 1b Con1 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luciferase reporter gene assay B 8.92 pEC50 1.2 nM EC50 Bioorg Med Chem Lett (2018) 28: 43-48 [PMID:29162454]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]