ChEMBL ligand: CHEMBL2105735 (BMS 650032, Asunaprevir, BMS-650032)
Hepatitis C virus NS3 protease/helicase in Hepatitis C virus [ChEMBL: CHEMBL4893] [UniProtKB: A3EZI9] This target only has 0 pki data point 1 CHEMBL2105735_lig_chart_1 Hepatitis C virus NS3 protease/helicase Hepatitis C virus There should be some charts here, you may need to enable JavaScript!
Hepatitis C virus serine protease, NS3/NS4A in Hepatitis C virus [ChEMBL: CHEMBL2095231] [UniProtKB: A3EZI9, D2K2A8] This target only has 0 pki data point 2 CHEMBL2105735_lig_chart_2 Hepatitis C virus serine protease, NS3/NS4A Hepatitis C virus There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Hepatitis C virus NS3 protease/helicase in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4893] [UniProtKB: A3EZI9]
ChEMBL	Inhibition of HCV genotype 1a H77 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luciferase reporter gene assay	B	8.4	pEC50	4	nM	EC50	Bioorg Med Chem Lett (2018) 28: 43-48 [PMID:29162454]
ChEMBL	Inhibition of HCV genotype 1b Con1 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luciferase reporter gene assay	B	8.92	pEC50	1.2	nM	EC50	Bioorg Med Chem Lett (2018) 28: 43-48 [PMID:29162454]
Hepatitis C virus serine protease, NS3/NS4A in Hepatitis C virus (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095231] [UniProtKB: A3EZI9, D2K2A8]
ChEMBL	Inhibition of recombinant full length HCV genotype 1a NS3/4A protease (1027 to 1711 residues) expressed in Escherichia coli strain BL21 (DE3) using RET S1 as substrate incubated for 1 min followed by substrate addition measured after 15 mins by FRET assay	B	9	pIC50	1	nM	IC50	ACS Med Chem Lett (2018) 9: 143-148 [PMID:29456803]
ChEMBL	Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET peptide substrate by FRET assay	B	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1853-1859 [PMID:29650290]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]