GC-376 [Ligand Id: 10883] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2365410
  • calpain 1 in Human [GtoPdb: 2336] [UniProtKB: P07384]
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  • cathepsin K in Human [GtoPdb: 2350] [UniProtKB: P43235]
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  • cathepsin L in Human [GtoPdb: 2351] [UniProtKB: P07711]
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  • CoV 3C-like (main) protease in SARS-CoV [GtoPdb: 3111] [UniProtKB: P0C6U8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
calpain 1 in Human [GtoPdb: 2336] [UniProtKB: P07384]
GtoPdb - - 7.13 pIC50 74 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]
cathepsin K in Human [GtoPdb: 2350] [UniProtKB: P43235]
GtoPdb - - 7.59 pIC50 26 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]
cathepsin L in Human [GtoPdb: 2351] [UniProtKB: P07711]
GtoPdb - - 8.36 pIC50 4.4 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]
CoV 3C-like (main) protease in SARS-CoV [GtoPdb: 3111] [UniProtKB: P0C6U8]
GtoPdb - - 7.3 pIC50 50 nM IC50 Nat Commun (2020) 11: 4282 [PMID:32855413]
GtoPdb - - 7.39 pIC50 41 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]