GC-376 [Ligand Id: 10883] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2365410
  • calpain 1 in Human [GtoPdb: 2336] [UniProtKB: P07384]
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  • cathepsin K in Human [GtoPdb: 2350] [UniProtKB: P43235]
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  • cathepsin L in Human [GtoPdb: 2351] [UniProtKB: P07711]
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  • CoV 3C-like (main) protease in SARS-CoV [GtoPdb: 3111] [UniProtKB: P0C6U8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
calpain 1 in Human [GtoPdb: 2336] [UniProtKB: P07384]
GtoPdb - - 7.13 pIC50 74 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]
cathepsin K in Human [GtoPdb: 2350] [UniProtKB: P43235]
GtoPdb - - 7.59 pIC50 26 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]
cathepsin L in Human [GtoPdb: 2351] [UniProtKB: P07711]
GtoPdb - - 8.36 pIC50 4.4 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]
CoV 3C-like (main) protease in SARS-CoV [GtoPdb: 3111] [UniProtKB: P0C6U8]
GtoPdb - - 7.3 pIC50 50 nM IC50 Nat Commun (2020) 11: 4282 [PMID:32855413]
GtoPdb - - 7.39 pIC50 41 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]