GC-376 [Ligand Id: 10883] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL2365410
There should be some charts here, you may need to enable JavaScript!
  • CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
There should be some charts here, you may need to enable JavaScript!
  • CoV 3C-like (main) protease/CoV Replicase polyprotein 1a in SARS-CoV-2 [GtoPdb: 3111, 3124] [UniProtKB: P0DTC1]
  • CoV 3C-like (main) protease/CoV Replicase polyprotein 1a/SARS coronavirus 3C-like proteinase in Severe acute respiratory syndrome-related coronavirus [ChEMBL: CHEMBL3927] [GtoPdb: 3111, 3124] [UniProtKB: P0C6U8]
There should be some charts here, you may need to enable JavaScript!
  • calpain 1 in Human [GtoPdb: 2336] [UniProtKB: P07384]
There should be some charts here, you may need to enable JavaScript!
  • cathepsin K in Human [GtoPdb: 2350] [UniProtKB: P43235]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711]
GtoPdb - - 8.36 pIC50 4.4 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]
ChEMBL Inhibition of human Cathepsin L using HiLyte Fluor488TM as substrate pre-incubated for 60 mins in presence of GSH followed by substrate addition measured after 30 mins by fluorescence based assay B 9 pIC50 1 nM IC50 Eur J Med Chem (2023) 250: 115186-115186 [PMID:36796300]
ChEMBL Inhibition of human Cathepsin L using HiLyte Fluor488TM as substrate pre-incubated for 60 mins in presence of GSH followed by substrate addition measured after 30 mins by fluorescence based assay B 9.16 pIC50 0.69 nM IC50 Eur J Med Chem (2023) 250: 115186-115186 [PMID:36796300]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL Inhibition of SARS-CoV-2 N-terminal 6His-SUMO-tagged 3CL protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-Glu-Edans fluorogenic peptide as substrate pre-incubated for 30 mins in presence of GSH followed by substrate addition measured after 30 mins by FRET assay B 7.64 pIC50 22.91 nM IC50 Eur J Med Chem (2023) 250: 115186-115186 [PMID:36796300]
ChEMBL Inhibition of SARS-CoV-2 N-terminal 6His-SUMO-tagged 3CL protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-Glu-Edans fluorogenic peptide as substrate pre-incubated for 30 mins in presence of GSH followed by substrate addition measured after 30 mins by FRET assay B 7.7 pIC50 20 nM IC50 Eur J Med Chem (2023) 250: 115186-115186 [PMID:36796300]
ChEMBL Inhibition of SARS-CoV-2 N-terminal 6His-SUMO-tagged 3CL protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-Glu-Edans fluorogenic peptide as substrate pre-incubated for 30 mins in absence of GSH followed by substrate addition measured after 30 mins by FRET assay B 7.92 pIC50 12.02 nM IC50 Eur J Med Chem (2023) 250: 115186-115186 [PMID:36796300]
ChEMBL Inhibition of SARS-CoV-2 N-terminal 6His-SUMO-tagged 3CL protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-Glu-Edans fluorogenic peptide as substrate pre-incubated for 30 mins in absence of GSH followed by substrate addition measured after 30 mins by FRET assay B 7.92 pIC50 12 nM IC50 Eur J Med Chem (2023) 250: 115186-115186 [PMID:36796300]
CoV 3C-like (main) protease/CoV Replicase polyprotein 1a in SARS-CoV-2 [GtoPdb: 3111, 3124] [UniProtKB: P0DTC1]
GtoPdb - - 6.39 pIC50 410 nM IC50 Proc Natl Acad Sci U S A (2021) 118: [PMID:34210738]
GtoPdb - - 6.72 pIC50 190 nM IC50 Nat Commun (2020) 11: 4282 [PMID:32855413]
GtoPdb - - 7.14 pIC50 73 nM IC50 J Am Chem Soc (2022) 144: 2905-2920 [PMID:35142215]
GtoPdb - - 7.39 pIC50 41 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]
GtoPdb - - 7.52 pIC50 30 nM IC50 Cell Res (2020) 30: 678-692 [PMID:32541865]
CoV 3C-like (main) protease/CoV Replicase polyprotein 1a/SARS coronavirus 3C-like proteinase in Severe acute respiratory syndrome-related coronavirus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3927] [GtoPdb: 3111, 3124] [UniProtKB: P0C6U8]
ChEMBL Inhibition of SARS-CoV N-terminal 6His-SUMO-tagged 3CL protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-Glu-Edans fluorogenic peptide as substrate pre-incubated for 30 mins in absence of GSH followed by substrate addition measured after 30 mins by FRET assay B 6.79 pIC50 162.18 nM IC50 Eur J Med Chem (2023) 250: 115186-115186 [PMID:36796300]
ChEMBL Inhibition of SARS-CoV N-terminal 6His-SUMO-tagged 3CL protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-Glu-Edans fluorogenic peptide as substrate pre-incubated for 30 mins in absence of GSH followed by substrate addition measured after 30 mins by FRET assay B 6.79 pIC50 161 nM IC50 Eur J Med Chem (2023) 250: 115186-115186 [PMID:36796300]
calpain 1 in Human [GtoPdb: 2336] [UniProtKB: P07384]
GtoPdb - - 7.13 pIC50 74 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]
cathepsin K in Human [GtoPdb: 2350] [UniProtKB: P43235]
GtoPdb - - 7.59 pIC50 26 nM IC50 ACS Pharmacol Transl Sci (2021) 4: 1408-1421 [PMID:34414360]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]