ChEMBL ligand: CHEMBL719 (Bactoderm, Bactroban, BRL 4910A, BRL-4910A, Centany, Mupirocin, NSC-759182, Pseudomonic acid, Trans-pseudomonic acid, Turixin)
Isoleucine--tRNA ligase in Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [ChEMBL: CHEMBL3879837] [UniProtKB: P56690] There should be some charts here, you may need to enable JavaScript!
Isoleucyl-tRNA synthetase in Human [ChEMBL: CHEMBL3235] [UniProtKB: P41252] Isoleucyl-tRNA synthetase in Escherichia coli [ChEMBL: CHEMBL3657] [UniProtKB: P00956] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum isoleucyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3168] [UniProtKB: Q8I5G6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Isoleucine--tRNA ligase in Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879837] [UniProtKB: P56690]
ChEMBL	Inhibition of recombinant Thermus thermophilus HB8 IleRS H581S/L583I double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation	B	4.82	pKi	15000	nM	Ki	Medchemcomm (2016) 7: 1535-1545
ChEMBL	Inhibition of recombinant Thermus thermophilus HB8 IleRS H581N/L583F double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation	B	5.56	pKi	2730	nM	Ki	Medchemcomm (2016) 7: 1535-1545
ChEMBL	Inhibition of recombinant Thermus thermophilus HB8 IleRS H581L/L583H double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation	B	5.64	pKi	2310	nM	Ki	Medchemcomm (2016) 7: 1535-1545
ChEMBL	Inhibition of recombinant Thermus thermophilus HB8 wild type IleRS assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation	B	6.6	pKi	250	nM	Ki	Medchemcomm (2016) 7: 1535-1545
ChEMBL	Inhibition of recombinant Thermus thermophilus HB8 IleRS L583F mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation	B	7.22	pKi	60	nM	Ki	Medchemcomm (2016) 7: 1535-1545
Isoleucyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3235] [UniProtKB: P41252]
ChEMBL	Compound was evaluated for inhibitory activity against Isoleucyl-tRNA synthetase	B	9.1	pIC50	0.8	nM	IC50	Bioorg Med Chem Lett (1997) 7: 2805-2808
Isoleucyl-tRNA synthetase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3657] [UniProtKB: P00956]
ChEMBL	Competitive inhibition of Escherichia coli Isoleucyl-tRNA synthetase	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2011) 46: 5227-5236 [PMID:21968372]
Plasmodium falciparum isoleucyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3168] [UniProtKB: Q8I5G6]
GtoPdb	-	-	7.24	pIC50	57.4	nM	IC50	Proc Natl Acad Sci U S A (2011) 108: 1627-32 [PMID:21205898]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]