CP-122288 [Ligand Id: 110] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL159332 (CP-122288)
  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 7.6 pIC50 - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 328-34 [PMID:9303569]
ChEMBL Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor B 7.84 pIC50 14.45 nM IC50 J. Med. Chem. (2001) 44: 681-693 [PMID:11262079]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 7.7 pIC50 - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 328-34 [PMID:9303569]
ChEMBL Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor B 8.14 pIC50 7.24 nM IC50 J. Med. Chem. (2001) 44: 681-693 [PMID:11262079]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]