NBI-35965 [Ligand Id: 11025] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL380800 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CRF1 receptor/Corticotropin releasing factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998] | ||||||||
| ChEMBL | Binding affinity for human corticotropin releasing factor receptor 1 expressed in LtK- cells using [125I]sauvagine | B | 8.5 | pKi | 3.16 | nM | Ki | J Med Chem (2005) 48: 5780-5793 [PMID:16134945] |
| ChEMBL | In vitro inhibition of CRF-stimulated cAMP production in cell membranes expressing human CRF1 receptor | F | 7.1 | pIC50 | 79.43 | nM | IC50 | J Med Chem (2005) 48: 5780-5793 [PMID:16134945] |
| CRF1 receptor in Rat [GtoPdb: 212] [UniProtKB: P35353] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | 4 | nM | Ki | Brain Res (2003) 985: 32-42 [PMID:12957366] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
