ARRY-371797 [Ligand Id: 11095] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1088750 (ARRY-371797, ARRY-797)
  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition of human recombinant p38alpha by liquid scintillation counting B 8.35 pIC50 4.5 nM IC50 J. Med. Chem. (2010) 53: 2345-2353 [PMID:19950901]
GtoPdb In vitro enzyme inhibition assay. - 8.35 pIC50 4.5 nM IC50 J. Med. Chem. (2010) 53: 2345-53 [PMID:19950901]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]