bavarostat [Ligand Id: 11119] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4165724 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC1 incubated for 90 mins using fluorogenic substrate ZMAL (Z-Lys(Ac)-AMC) by fluorescence based assay | B | 3 | pIC50 | >1000000 | nM | IC50 | J Med Chem (2018) 61: 8054-8060 [PMID:30118224] |
| ChEMBL | Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate by fluorescence assay | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2019) 62: 8557-8577 [PMID:31414801] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2018) 61: 8054-8060 [PMID:30118224] |
| ChEMBL | Inhibition of human recombinant HDAC6 incubated for 90 mins using fluorogenic substrate ZMAL (Z-Lys(Ac)-AMC) by fluorescence based assay | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2018) 61: 8054-8060 [PMID:30118224] |
| ChEMBL | Inhibition of human recombinant HDAC6 using fluorogenic HDAC substrate by fluorescence assay | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2019) 62: 8557-8577 [PMID:31414801] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
