DPO-1 [Ligand Id: 11207] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1088844
  • Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1088844_lig_chart_1 Voltage-gated potassium channel subunit Kv1.5 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460]
ChEMBL Inhibition of human Kv1.5 ion channel after 3 mins by high-throughput planar patch clamp assay B 6.3 pIC50 500 nM IC50 ACS Med. Chem. Lett. (2012) 3: 769-773 [PMID:24900546]
GtoPdb Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay. - 7.3 pIC50 50 nM IC50 Bioorg Med Chem Lett (2010) 20: 2493-6 [PMID:20304642]
ChEMBL Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay B 7.52 pIC50 30 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 2493-2496 [PMID:20304642]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]