ChEMBL ligand: CHEMBL2023898 (BMS 790052, BMS-790052, Daclatasvir, Daklinza, EBP 883, EBP-883)
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Nonstructural protein 5A in Hepatitis C virus [ChEMBL: CHEMBL3307224] [UniProtKB: Q5L478] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG by whole cell patch clamp assay	B	4.53	pIC50	29200	nM	IC50	J Med Chem (2014) 57: 2013-2032 [PMID:24521299]
Nonstructural protein 5A in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3307224] [UniProtKB: Q5L478]
ChEMBL	Inhibition of NS5A in HCV genotype 1b infected in human HuH7.5/Con1/SG-Neo(I)-hRluc2aUb cells assessed as inhibition of replicon levels incubated for 72 hrs by luciferase reporter gene assay	B	10.64	pIC50	0.02	nM	IC50	J Med Chem (2019) 62: 10563-10582 [PMID:31710479]
ChEMBL	Inhibition of Hepatitis C virus 1a NS5A Q30E mutant	B	5.9	pEC50	1260	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127361-127361 [PMID:32738974]
ChEMBL	Inhibition of Hepatitis C virus 1a NS5A Q30R mutant	B	7.21	pEC50	61	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127361-127361 [PMID:32738974]
ChEMBL	Inhibition of NS5A in HCV genotype 2a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay	B	7.28	pEC50	52.85	nM	EC50	J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL	Inhibition of NS5A in patient-derived HCV genotype 2a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay	B	7.31	pEC50	49.4	nM	EC50	J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL	Inhibition of NS5A in HCV genotype 3a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay	B	9.39	pEC50	0.41	nM	EC50	J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL	Inhibition of Hepatitis C virus 3a NS5A	B	9.84	pEC50	0.15	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127361-127361 [PMID:32738974]
ChEMBL	Inhibition of NS5A in patient-derived HCV genotype 3a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay	B	9.94	pEC50	0.11	nM	EC50	J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL	Inhibition of HCV genotype 1a NS5A infected in HuH-7-Luc/Neo-ET cells assessed as reduction in viral replication measured by Luciferase reporter gene assay	B	10.1	pEC50	0.08	nM	EC50	ACS Med Chem Lett (2021) 12: 1649-1655 [PMID:34790290]
ChEMBL	Inhibition of Hepatitis C virus 2a NS5A	B	10.15	pEC50	0.07	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127361-127361 [PMID:32738974]
ChEMBL	Inhibition of NS5A in Hepatitis C virus subtype 2a replicon assessed as reduction in viral replication using Ac-Asp-Glu-Asp (EDANS)-Glu-Glu-Abu-(COO) Ala-Ser-Lys (DABCYL)-NH2 as substrate measured after 72 hrs by FRET assay	B	10.15	pEC50	0.07	nM	EC50	Bioorg Med Chem Lett (2020) 30: 126932-126932 [PMID:31952964]
ChEMBL	Inhibition of Hepatitis C virus 1a H77 NS5A	B	10.3	pEC50	0.05	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127361-127361 [PMID:32738974]
ChEMBL	Inhibition of NS5A in Hepatitis C virus subtype 1a replicon assessed as reduction in viral replication using Ac-Asp-Glu-Asp (EDANS)-Glu-Glu-Abu-(COO) Ala-Ser-Lys (DABCYL)-NH2 as substrate measured after 72 hrs by FRET assay	B	10.3	pEC50	0.05	nM	EC50	Bioorg Med Chem Lett (2020) 30: 126932-126932 [PMID:31952964]
ChEMBL	Inhibition of NS5A in HCV genotype 1a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay	B	10.49	pEC50	0.03	nM	EC50	J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL	Inhibition of HCV genotype 1b NS5A infected in HuH-7-Luc/Neo-ET cells assessed as reduction in viral replication measured by Luciferase reporter gene assay	B	10.49	pEC50	0.03	nM	EC50	ACS Med Chem Lett (2021) 12: 1649-1655 [PMID:34790290]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]