daclatasvir [Ligand Id: 11266] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2023898 (Daclatasvir, BMS-790052, EBP-883, BMS 790052, EBP 883, Daklinza)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG by whole cell patch clamp assay B 4.53 pIC50 29200 nM IC50 J. Med. Chem. (2014) 57: 2013-2032 [PMID:24521299]
Nonstructural protein 5A in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3307224] [UniProtKB: Q5L478]
ChEMBL Inhibition of NS5A in HCV genotype 1b infected in human HuH7.5/Con1/SG-Neo(I)-hRluc2aUb cells assessed as inhibition of replicon levels incubated for 72 hrs by luciferase reporter gene assay B 10.64 pIC50 0.02 nM IC50 J Med Chem (2019) 62: 10563-10582 [PMID:31710479]
ChEMBL Inhibition of NS5A in HCV genotype 2a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay B 7.28 pEC50 52.85 nM EC50 J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL Inhibition of NS5A in patient-derived HCV genotype 2a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay B 7.31 pEC50 49.4 nM EC50 J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL Inhibition of NS5A in HCV genotype 3a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay B 9.39 pEC50 0.41 nM EC50 J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL Inhibition of NS5A in patient-derived HCV genotype 3a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay B 9.94 pEC50 0.11 nM EC50 J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL Inhibition of NS5A in HCV genotype 1a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay B 10.49 pEC50 0.03 nM EC50 J Med Chem (2020) 63: 4155-4170 [PMID:32202782]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]