ChEMBL ligand: CHEMBL2023898 (BMS 790052, BMS-790052, Daclatasvir, Daklinza, EBP 883, EBP-883)
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Nonstructural protein 5A in Hepatitis C virus [ChEMBL: CHEMBL3307224] [UniProtKB: Q5L478] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG by whole cell patch clamp assay	B	4.53	pIC50	29200	nM	IC50	J Med Chem (2014) 57: 2013-2032 [PMID:24521299]
Nonstructural protein 5A in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3307224] [UniProtKB: Q5L478]
ChEMBL	Inhibition of NS5A in HCV genotype 1b infected in human HuH7.5/Con1/SG-Neo(I)-hRluc2aUb cells assessed as inhibition of replicon levels incubated for 72 hrs by luciferase reporter gene assay	B	10.64	pIC50	0.02	nM	IC50	J Med Chem (2019) 62: 10563-10582 [PMID:31710479]
ChEMBL	Inhibition of Hepatitis C virus 1a NS5A Q30E mutant	B	5.9	pEC50	1260	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127361-127361 [PMID:32738974]
ChEMBL	Inhibition of Hepatitis C virus 1a NS5A Q30R mutant	B	7.21	pEC50	61	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127361-127361 [PMID:32738974]
ChEMBL	Inhibition of NS5A in HCV genotype 2a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay	B	7.28	pEC50	52.85	nM	EC50	J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL	Inhibition of NS5A in patient-derived HCV genotype 2a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay	B	7.31	pEC50	49.4	nM	EC50	J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL	Inhibition of NS5A in HCV genotype 3a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay	B	9.39	pEC50	0.41	nM	EC50	J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL	Inhibition of Hepatitis C virus 3a NS5A	B	9.84	pEC50	0.15	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127361-127361 [PMID:32738974]
ChEMBL	Inhibition of NS5A in patient-derived HCV genotype 3a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay	B	9.94	pEC50	0.11	nM	EC50	J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL	Inhibition of HCV genotype 1a NS5A infected in HuH-7-Luc/Neo-ET cells assessed as reduction in viral replication measured by Luciferase reporter gene assay	B	10.1	pEC50	0.08	nM	EC50	ACS Med Chem Lett (2021) 12: 1649-1655 [PMID:34790290]
ChEMBL	Inhibition of Hepatitis C virus 2a NS5A	B	10.15	pEC50	0.07	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127361-127361 [PMID:32738974]
ChEMBL	Inhibition of NS5A in Hepatitis C virus subtype 2a replicon assessed as reduction in viral replication using Ac-Asp-Glu-Asp (EDANS)-Glu-Glu-Abu-(COO) Ala-Ser-Lys (DABCYL)-NH2 as substrate measured after 72 hrs by FRET assay	B	10.15	pEC50	0.07	nM	EC50	Bioorg Med Chem Lett (2020) 30: 126932-126932 [PMID:31952964]
ChEMBL	Inhibition of Hepatitis C virus 1a H77 NS5A	B	10.3	pEC50	0.05	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127361-127361 [PMID:32738974]
ChEMBL	Inhibition of NS5A in Hepatitis C virus subtype 1a replicon assessed as reduction in viral replication using Ac-Asp-Glu-Asp (EDANS)-Glu-Glu-Abu-(COO) Ala-Ser-Lys (DABCYL)-NH2 as substrate measured after 72 hrs by FRET assay	B	10.3	pEC50	0.05	nM	EC50	Bioorg Med Chem Lett (2020) 30: 126932-126932 [PMID:31952964]
ChEMBL	Inhibition of NS5A in HCV genotype 1a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay	B	10.49	pEC50	0.03	nM	EC50	J Med Chem (2020) 63: 4155-4170 [PMID:32202782]
ChEMBL	Inhibition of HCV genotype 1b NS5A infected in HuH-7-Luc/Neo-ET cells assessed as reduction in viral replication measured by Luciferase reporter gene assay	B	10.49	pEC50	0.03	nM	EC50	ACS Med Chem Lett (2021) 12: 1649-1655 [PMID:34790290]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]