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ChEMBL ligand: CHEMBL2023898 (Daclatasvir, BMS-790052, EBP-883, BMS 790052, EBP 883, Daklinza) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG by whole cell patch clamp assay | B | 4.53 | pIC50 | 29200 | nM | IC50 | J. Med. Chem. (2014) 57: 2013-2032 [PMID:24521299] |
Nonstructural protein 5A in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3307224] [UniProtKB: Q5L478] | ||||||||
ChEMBL | Inhibition of NS5A in HCV genotype 1b infected in human HuH7.5/Con1/SG-Neo(I)-hRluc2aUb cells assessed as inhibition of replicon levels incubated for 72 hrs by luciferase reporter gene assay | B | 10.64 | pIC50 | 0.02 | nM | IC50 | J Med Chem (2019) 62: 10563-10582 [PMID:31710479] |
ChEMBL | Inhibition of NS5A in HCV genotype 2a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay | B | 7.28 | pEC50 | 52.85 | nM | EC50 | J Med Chem (2020) 63: 4155-4170 [PMID:32202782] |
ChEMBL | Inhibition of NS5A in patient-derived HCV genotype 2a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay | B | 7.31 | pEC50 | 49.4 | nM | EC50 | J Med Chem (2020) 63: 4155-4170 [PMID:32202782] |
ChEMBL | Inhibition of NS5A in HCV genotype 3a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay | B | 9.39 | pEC50 | 0.41 | nM | EC50 | J Med Chem (2020) 63: 4155-4170 [PMID:32202782] |
ChEMBL | Inhibition of NS5A in patient-derived HCV genotype 3a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay | B | 9.94 | pEC50 | 0.11 | nM | EC50 | J Med Chem (2020) 63: 4155-4170 [PMID:32202782] |
ChEMBL | Inhibition of NS5A in HCV genotype 1a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter gene assay | B | 10.49 | pEC50 | 0.03 | nM | EC50 | J Med Chem (2020) 63: 4155-4170 [PMID:32202782] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]