dasabuvir [Ligand Id: 11270] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3137312 (ABT-333, Dasabuvir)
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  • RNA-directed RNA polymerase in Hepacivirus hominis [ChEMBL: CHEMBL4296320] [UniProtKB: O39930]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cereblon/Protein cereblon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3763008] [GtoPdb: 3086] [UniProtKB: Q96SW2]
ChEMBL Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MST based assay B 5.33 pKi 4710 nM Ki ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967]
ChEMBL Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MST based assay B 4.81 pIC50 15600 nM IC50 ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967]
RNA-directed RNA polymerase in Hepacivirus hominis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296320] [UniProtKB: O39930]
ChEMBL Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase B 8.74 pEC50 1.8 nM EC50 Medchemcomm (2019) 10: 991-1006 [PMID:31303998]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]