dasabuvir [Ligand Id: 11270] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3137312 (ABT-333, Dasabuvir, Exviera)
  • Hepatitis C virus NS5B RNA-dependent RNA polymerase in Hepatitis C virus [ChEMBL: CHEMBL5375] [UniProtKB: Q8JXU8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Hepatitis C virus NS5B RNA-dependent RNA polymerase in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5375] [UniProtKB: Q8JXU8]
ChEMBL Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase B 8.74 pEC50 1.8 nM EC50 MedChemComm (2019) 10: 991-1006

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]