UK-5099 [Ligand Id: 11302] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL4303684
There should be some charts here, you may need to enable JavaScript!
  • mitochondrial pyruvate carrier 1 in Rat [GtoPdb: 3022] [UniProtKB: P63031]
There should be some charts here, you may need to enable JavaScript!
  • mitochondrial pyruvate carrier 2 in Rat [GtoPdb: 3023] [UniProtKB: P38718]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Monocarboxylate transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073709] [GtoPdb: 988] [UniProtKB: P53987]
ChEMBL Inhibition of MCT1 in rat Brain-like endothelial cells incubated for 15 mins in presence of [14C]lactic acid by scintillation counter assay B 7.89 pIC50 12.8 nM IC50 Eur J Med Chem (2020) 199: 112393-112393 [PMID:32388280]
mitochondrial pyruvate carrier 1 in Rat [GtoPdb: 3022] [UniProtKB: P63031]
GtoPdb - - 7.3 pIC50 50 nM IC50 Biochem J (1975) 148: 85-96 [PMID:1156402]
mitochondrial pyruvate carrier 2 in Rat [GtoPdb: 3023] [UniProtKB: P38718]
GtoPdb - - 7.3 pIC50 50 nM IC50 Biochem J (1975) 148: 85-96 [PMID:1156402]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]