borrelidin [Ligand Id: 11306] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL70590 (Borrelidin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546] | ||||||||
| ChEMBL | Inhibition of cyclin-dependent kinase activity of Cdc28p/CDK2p in Saccharomyces cerevisiae | B | 4.62 | pIC50 | 24000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2235-2237 [PMID:12798341] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against drug-resistant asynchronous culture of Plasmodium falciparum K1 after 72 hrs by p-LDH assay | F | 8.72 | pIC50 | 1.9 | nM | IC50 | Medchemcomm (2016) 7: 1535-1545 |
| Plasmodium falciparum threonyl-tRNA synthetase/threonine--tRNA ligase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5465377] [GtoPdb: 3058] [UniProtKB: Q8IIA4] | ||||||||
| ChEMBL | Inhibition of Plasmodium falciparum Threonyl tRNA synthetase expressed in Escherichia coli Rossetta 2 (DE3) assessed as apparent inhibition constant by measuring formation of Thr-tRNA Thr using [14C]threonine and unlabeled threonine by scintillation counting analysis | B | 6.8 | pKi | 160 | nM | Ki | ACS Med Chem Lett (2024) 15: 76-80 [PMID:38229753] |
| ChEMBL | Inhibition of Plasmodium falciparum Threonyl tRNA synthetase | B | 7.37 | pIC50 | 43 | nM | IC50 | ACS Med Chem Lett (2024) 15: 76-80 [PMID:38229753] |
| Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum FCR3 [GtoPdb: 3058] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 8.74 | pIC50 | 1.8 | nM | IC50 | J Antibiot (Tokyo) (2003) 56: 727-9 [PMID:14563165] |
| Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3058] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 8.72 | pIC50 | 1.9 | nM | IC50 | J Antibiot (Tokyo) (2003) 56: 727-9 [PMID:14563165] |
| Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3058] [UniProtKB: Q8IIA4] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 8.91 | pIC50 | 1.24 | nM | IC50 | Proc Natl Acad Sci U S A (2014) 111: E5508-17 [PMID:25489076] |
| GtoPdb | Parasite growth inhibition assay | - | 9.01 | pIC50 | 0.97 | nM | IC50 | Proc Natl Acad Sci U S A (2014) 111: E5508-17 [PMID:25489076] |
| Threonyl-tRNA synthase in Phytophthora sojae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366435] [UniProtKB: G3FIN0] | ||||||||
| ChEMBL | Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduction in initial velocity at the step of threonine activation preincubated for 10 min with 4 uM enzyme before threonine addition measured after 30 min by HPLC analysis | B | 5 | pKi | 10000 | nM | Ki | J Agric Food Chem (2012) 60: 9874-9881 [PMID:22967236] |
| ChEMBL | Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduction in initial velocity at the step of threonine activation preincubated for 10 min with 4 uM enzyme before threonine addition measured after 30 min by HPLC analysis | B | 5.1 | pIC50 | 8000 | nM | IC50 | J Agric Food Chem (2012) 60: 9874-9881 [PMID:22967236] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
