borrelidin [Ligand Id: 11306] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL70590 (Borrelidin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546] | ||||||||
| ChEMBL | Inhibition of cyclin-dependent kinase activity of Cdc28p/CDK2p in Saccharomyces cerevisiae | B | 4.62 | pIC50 | 24000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2235-2237 [PMID:12798341] |
| Threonyl-tRNA synthase in Phytophthora sojae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366435] [UniProtKB: G3FIN0] | ||||||||
| ChEMBL | Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduction in initial velocity at the step of threonine activation preincubated for 10 min with 4 uM enzyme before threonine addition measured after 30 min by HPLC analysis | B | 5 | pKi | 10000 | nM | Ki | J Agric Food Chem (2012) 60: 9874-9881 [PMID:22967236] |
| ChEMBL | Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduction in initial velocity at the step of threonine activation preincubated for 10 min with 4 uM enzyme before threonine addition measured after 30 min by HPLC analysis | B | 5.1 | pIC50 | 8000 | nM | IC50 | J Agric Food Chem (2012) 60: 9874-9881 [PMID:22967236] |
| Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum FCR3 [GtoPdb: 3058] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 8.74 | pIC50 | 1.8 | nM | IC50 | J Antibiot (Tokyo) (2003) 56: 727-9 [PMID:14563165] |
| Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3058] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 8.72 | pIC50 | 1.9 | nM | IC50 | J Antibiot (Tokyo) (2003) 56: 727-9 [PMID:14563165] |
| Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3058] [UniProtKB: Q8IIA4] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 8.91 | pIC50 | 1.24 | nM | IC50 | Proc Natl Acad Sci U S A (2014) 111: E5508-17 [PMID:25489076] |
| GtoPdb | Parasite growth inhibition assay | - | 9.01 | pIC50 | 0.97 | nM | IC50 | Proc Natl Acad Sci U S A (2014) 111: E5508-17 [PMID:25489076] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
