liraglutide [Ligand Id: 1133] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201866 (Victoza, Liraglutide recombinant)
  • GLP-1 receptor/Glucagon-like peptide 1 receptor in Human [ChEMBL: CHEMBL1784] [GtoPdb: 249] [UniProtKB: P43220]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GLP-1 receptor/Glucagon-like peptide 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1784] [GtoPdb: 249] [UniProtKB: P43220]
ChEMBL Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin B 8.32 pIC50 4.78 nM IC50 J. Med. Chem. (2015) 58: 7370-7380 [PMID:26308095]
ChEMBL Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin B 9.96 pIC50 0.11 nM IC50 J. Med. Chem. (2015) 58: 7370-7380 [PMID:26308095]
GtoPdb - - 10.2 pEC50 - - - J Med Chem (2000) 43: 1664-9 [PMID:10794683]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]