miltefosine [Ligand Id: 11355] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL125 (D-18506, HDPC, Impavido, Miltefosine, Miltex, NSC-605583, NSC-758968) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dual specificity phosphatase Cdc25A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3775] [UniProtKB: P30304] | ||||||||
| ChEMBL | Inhibition of Cell division cycle 25 (Cdc25) phosphatase | B | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (1996) 39: 2609-2614 [PMID:8691459] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG incubated for 2 hrs by fluorescence polarisation assay | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2018) 146: 423-434 [PMID:29407968] |
| AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| ChEMBL | Inhibition of Akt phosphorylation in human insulin-stimulated A549 cells incubated for 2 hrs prior to insulin-induction measured after 30 mins by ELISA | B | 5.02 | pIC50 | 9600 | nM | IC50 | Bioorg Med Chem (2013) 21: 2018-2024 [PMID:23415083] |
| GtoPdb | Measuring inhibition of AKT1 phosphorylation in A549 human epithelial lung cancer cells. | - | 5.02 | pIC50 | 9600 | nM | IC50 | Bioorg Med Chem (2013) 21: 2018-24 [PMID:23415083] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
