ChEMBL ligand: CHEMBL134713 (3-(2,4-Dimethoxybenzylidene)Anabaseine, Dimethoxybenzylidene anabaseine, Dmxb-a, Gts-21)
Acetylcholine-binding protein in Lymnaea stagnalis [ChEMBL: CHEMBL6084] [UniProtKB: P58154] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α1 subunit/nicotinic acetylcholine receptor γ subunit/nicotinic acetylcholine receptor β1 subunit/nicotinic acetylcholine receptor δ subunit/Acetylcholine receptor; alpha1/beta1/delta/gamma in Human [ChEMBL: CHEMBL1907588] [GtoPdb: 462, 475, 471, 476] [UniProtKB: P02708, P07510, P11230, Q07001] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Human [ChEMBL: CHEMBL1907594] [GtoPdb: 474, 464] [UniProtKB: P30926, P32297] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681] nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat [ChEMBL: CHEMBL1907596] [GtoPdb: 465, 472] [UniProtKB: P09483, P12390] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta4 in Human [ChEMBL: CHEMBL1907591] [GtoPdb: 474, 465] [UniProtKB: P30926, P43681] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544] nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Acetylcholine-binding protein in Lymnaea stagnalis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6084] [UniProtKB: P58154]
ChEMBL	Displacement of [3H]-epibatidine from Lymnaea stagnalis N-terminal FLAG-tagged AChBP expressed in HEK293 cells after 2 hrs by liquid scintillation counting	B	7.72	pKd	19	nM	Kd	Eur J Med Chem (2011) 46: 5625-5635 [PMID:21986237]
nicotinic acetylcholine receptor α1 subunit/nicotinic acetylcholine receptor γ subunit/nicotinic acetylcholine receptor β1 subunit/nicotinic acetylcholine receptor δ subunit/Acetylcholine receptor; alpha1/beta1/delta/gamma in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907588] [GtoPdb: 462, 475, 471, 476] [UniProtKB: P02708, P07510, P11230, Q07001]
ChEMBL	Displacement of [3H]-epibatidine from alpha1betagammadelta nAChR in human TE671 cellular membranes after 2 hrs by liquid scintillation counting	B	5.41	pKi	3900	nM	Ki	Eur J Med Chem (2011) 46: 5625-5635 [PMID:21986237]
ChEMBL	Displacement of [3H]epibatidine from human alpha1/beta/gamma/delta nAchR expressed in TE-671 cell membrane	B	5.41	pKi	3900	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1179-1186 [PMID:22177081]
nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907594] [GtoPdb: 474, 464] [UniProtKB: P30926, P32297]
ChEMBL	Displacement of [3H]-epibatidine from alpha3beta4 nAChR in human SH-SY5Y cellular membranes after 2 hrs by liquid scintillation counting	B	5.6	pKi	2500	nM	Ki	Eur J Med Chem (2011) 46: 5625-5635 [PMID:21986237]
ChEMBL	Displacement of [3H]epibatidine from human alpha3beta4 nAchR expressed in SH-SY5Y cells	B	5.6	pKi	2500	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1179-1186 [PMID:22177081]
ChEMBL	Effective concentration against Nicotinic acetylcholine receptor alpha3-beta4	B	5	pEC50	>10000	nM	EC50	J Med Chem (2005) 48: 4705-4745 [PMID:16033252]
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681]
ChEMBL	Displacement of [3H]epibatidine from human alpha4beta2 nAchR expressed in SH-EP1 cells	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1179-1186 [PMID:22177081]
ChEMBL	Effective concentration against Nicotinic acetylcholine receptor alpha4-beta2	B	5	pEC50	>10000	nM	EC50	J Med Chem (2005) 48: 4705-4745 [PMID:16033252]
nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907596] [GtoPdb: 465, 472] [UniProtKB: P09483, P12390]
ChEMBL	Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membrane after 3 hrs	B	0.6	pKi	0.6	uM	pKi	Eur J Med Chem (2010) 45: 2433-2446 [PMID:20236734]
ChEMBL	Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membrane after 3 hrs	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2010) 45: 2433-2446 [PMID:20236734]
ChEMBL	Inhibition of [3H]cytisine binding to nicotinic acetylcholine receptor alpha4-beta2 from rat cerebral cortex	B	7.08	pKi	84	nM	Ki	J Med Chem (2005) 48: 2678-2686 [PMID:15801858]
ChEMBL	Displacement of [3H]-epibatidine from alpha4beta2 nAChR in rat cortical membranes after 2 hrs by liquid scintillation counting	B	7.29	pKi	51	nM	Ki	Eur J Med Chem (2011) 46: 5625-5635 [PMID:21986237]
nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta4 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907591] [GtoPdb: 474, 465] [UniProtKB: P30926, P43681]
ChEMBL	Effective concentration against Nicotinic acetylcholine receptor alpha4-beta4	B	5	pEC50	>10000	nM	EC50	J Med Chem (2005) 48: 4705-4745 [PMID:16033252]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544]
ChEMBL	Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR	B	6.8	pKd	158	nM	Kd	J Med Chem (2008) 51: 6293-6302 [PMID:18826295]
ChEMBL	Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes incubated for 90 secs followed by washout period for 5 mins by electrophysiological method	B	5.22	pEC50	6000	nM	EC50	Eur J Med Chem (2018) 160: 37-48 [PMID:30317024]
ChEMBL	Agonist activity at human recombinant alpha7 nAChR expressed in rat GH3 cells by calcium influx assay	F	5.7	pEC50	1995.26	nM	EC50	Bioorg Med Chem Lett (2009) 19: 1287-1291 [PMID:19208472]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941]
ChEMBL	Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in rat brain membrane after 3 hrs	B	0.89	pKi	0.89	uM	pKi	Eur J Med Chem (2010) 45: 2433-2446 [PMID:20236734]
ChEMBL	Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation counting	B	5.89	pKi	1300	nM	Ki	Eur J Med Chem (2011) 46: 5625-5635 [PMID:21986237]
ChEMBL	Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7	B	6.66	pKi	220	nM	Ki	J Med Chem (2005) 48: 2678-2686 [PMID:15801858]
GtoPdb	Inhibition of [125I]alpha-bungarotoxin binding to rat α nAChR	-	6.66	pKi	220	nM	Ki	J Med Chem (2005) 48: 2678-86 [PMID:15801858]
ChEMBL	Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in rat brain membrane after 3 hrs	B	6.89	pKi	130	nM	Ki	Eur J Med Chem (2010) 45: 2433-2446 [PMID:20236734]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]