ChEMBL ligand: CHEMBL274990 (SC-58125)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] COX-2 /Cyclooxygenase-2 in Mouse [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 1 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 production	B	4	pIC50	>100000	nM	IC50	J Med Chem (1997) 40: 980-989 [PMID:9083488]
ChEMBL	In vitro inhibition of prostaglandin G/H synthase 1.	B	4	pIC50	>100000	nM	IC50	J Med Chem (1995) 38: 4570-4578 [PMID:7473585]
ChEMBL	Tested for inhibition against Prostaglandin G/H synthase 1	B	4	pIC50	>100000	nM	IC50	J Med Chem (1994) 37: 3878-3881 [PMID:7966148]
ChEMBL	In vitro inhibitory concentration against recombinant human COX-1 (Cyclooxygenase-1)	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (1997) 7: 2121-2124
ChEMBL	Inhibitory activity against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf9 cells	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem Lett (1996) 6: 87-92
ChEMBL	Inhibition of human COX1 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay	B	4.49	pIC50	32000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4509-4514 [PMID:19523822]
ChEMBL	IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasma	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (1999) 42: 1161-1169 [PMID:10197960]
ChEMBL	IC50 against Prostaglandin G/H synthase 1 from human platelet rich plasma	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (1999) 42: 1151-1160 [PMID:10197959]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	IC50 value against ovine Prostaglandin G/H synthase 1	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (1999) 42: 1161-1169 [PMID:10197960]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of COX-2 (unknown origin)	B	5.96	pIC50	1100	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1516-1520 [PMID:26898334]
ChEMBL	IC50 against recombinant human Prostaglandin G/H synthase 2	B	6.51	pIC50	310	nM	IC50	J Med Chem (1999) 42: 1151-1160 [PMID:10197959]
ChEMBL	Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2)	B	6.51	pIC50	310	nM	IC50	J Med Chem (1999) 42: 1161-1169 [PMID:10197960]
ChEMBL	Inhibitory activity against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf9 cells	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (1996) 6: 87-92
ChEMBL	Inhibition of human cyclooxygenase-2 (hCOX-2) enzyme.	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1167-1170 [PMID:10328306]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 2	B	7	pIC50	100	nM	IC50	J Med Chem (2001) 44: 3223-3230 [PMID:11563921]
ChEMBL	In vitro inhibitory concentration against human Prostaglandin G/H synthase 2	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (1997) 7: 2121-2124
ChEMBL	In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)	B	7	pIC50	100	nM	IC50	J Med Chem (1997) 40: 1347-1365 [PMID:9135032]
ChEMBL	Tested for inhibition against Prostaglandin G/H synthase 2	B	7.05	pIC50	90	nM	IC50	J Med Chem (1994) 37: 3878-3881 [PMID:7966148]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 production	B	7.05	pIC50	90	nM	IC50	J Med Chem (1997) 40: 980-989 [PMID:9083488]
ChEMBL	Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay	B	7.18	pIC50	66	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4509-4514 [PMID:19523822]
ChEMBL	In vitro inhibition of prostaglandin G/H synthase 2 (COX-2).	B	7.3	pIC50	50	nM	IC50	J Med Chem (1995) 38: 4570-4578 [PMID:7473585]
GtoPdb	-	-	7.39	pIC50	-	-	-	J Biol Chem (1996) 271: 15810-4 [PMID:8663121]
COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769]
ChEMBL	IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines.	B	7.15	pIC50	70	nM	IC50	J Med Chem (1999) 42: 1151-1160 [PMID:10197959]
ChEMBL	IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell line	B	7.15	pIC50	70	nM	IC50	J Med Chem (1999) 42: 1161-1169 [PMID:10197960]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]