secretin receptor in Human [GtoPdb: 252] [UniProtKB: P47872] secretin receptor in Rat [GtoPdb: 252] [UniProtKB: P23811] There should be some charts here, you may need to enable JavaScript!
PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586] PAC1 receptor in Rat [GtoPdb: 370] [UniProtKB: P32215] There should be some charts here, you may need to enable JavaScript!
VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241] VPAC1 receptor in Rat [GtoPdb: 371] [UniProtKB: P30083] There should be some charts here, you may need to enable JavaScript!
VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587] VPAC2 receptor in Rat [GtoPdb: 372] [UniProtKB: P35000] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
secretin receptor in Human [GtoPdb: 252] [UniProtKB: P47872]
GtoPdb	-	-	5.4	pIC50	-	-	-	EMBO J (1991) 10: 1635-41 [PMID:1646711]
secretin receptor in Rat [GtoPdb: 252] [UniProtKB: P23811]
GtoPdb	Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor	-	6.2	pIC50	600	nM	IC50	Peptides (1997) 18: 1539-45 [PMID:9437714]
PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586]
GtoPdb	inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the PAC1 very short receptor	-	6	pKi	>1000	nM	Ki	J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729]
GtoPdb	inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the full length receptor (ENST00000304166)	-	6.3	pKi	458	nM	Ki	J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729]
GtoPdb	inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the PAC1 short receptor (ENST00000409363)	-	8.4	pKi	4.4	nM	Ki	J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729]
GtoPdb	inhibition of [125I]-PACAP-27 binding to membranes from NIH/3T3 cells stably expressing the recombinant receptor	-	6	pIC50	>1000	nM	IC50	J Mol Neurosci (2002) 18: 29-35 [PMID:11931347]
GtoPdb	stimulation of cyclic AMP formation in NIH/3T3 cells stably expressing the recombinant receptor	-	6	pEC50	>1000	nM	EC50	J Mol Neurosci (2002) 18: 29-35 [PMID:11931347]
GtoPdb	stimulation of cyclic AMP formation in HEK293 cells stably expressing the PAC1 very short receptor	-	6.4	pEC50	373	nM	EC50	J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729]
GtoPdb	calcium influx in CHO cells stably expressing recombinant receptor	-	6.4	pEC50	389	nM	EC50	Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb	stimulation of cyclic AMP formation in HEK293 cells stably expressing the full length receptor (ENST00000304166)	-	6.7	pEC50	186	nM	EC50	J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729]
GtoPdb	cyclic AMP formation in CHO cells stably expressing recombinant receptor	-	7.8	pEC50	15.1	nM	EC50	Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb	stimulation of cyclic AMP formation in HEK293 cells stably expressing the PAC1 short receptor (ENST00000409363)	-	8.7	pEC50	2.1	nM	EC50	J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729]
PAC1 receptor in Rat [GtoPdb: 370] [UniProtKB: P32215]
GtoPdb	inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the rat PAC1 receptor isoform including the hop1 exon	-	5.5	pKi	3500	nM	Ki	Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670]
GtoPdb	inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the rat PAC1 receptor isoform including the hop1 exon	-	5.8	pKi	1500	nM	Ki	Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670]
GtoPdb	Inhibition of [125I]-Ac-His1-PACAP-27 binding in membranes from CHO cells expressing recombinant receptor	-	5.7	pIC50	2000	nM	IC50	Peptides (1997) 18: 1539-45 [PMID:9437714]
GtoPdb	stimulation of adenylate cyclase in CHO cells stably expressing the rat PAC1 receptor isoform including the hop1 exon	-	7.1	pEC50	80	nM	EC50	Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670]
GtoPdb	stimulation of adenylate cyclase in CHO cells stably expressing the rat PAC1 receptor isoform lacking the hip and hop exons	-	7.1	pEC50	80	nM	EC50	Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670]
VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241]
GtoPdb	inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor	-	8.5	pKi	3.4	nM	Ki	J Pharmacol Exp Ther (1997) 281: 629-33 [PMID:9152366]
GtoPdb	inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor	-	8.9	pKi	1.4	nM	Ki	J Pharmacol Exp Ther (1998) 284: 744-50 [PMID:9454823]
GtoPdb	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	-	9	pKi	0.9	nM	Ki	J Biol Chem (2000) 275: 24003-12 [PMID:10801840]
GtoPdb	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	-	9	pKi	0.9	nM	Ki	Eur J Pharmacol (1996) 302: 207-14 [PMID:8791009]
GtoPdb	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	-	9.1	pKi	0.82	nM	Ki	Biochem Biophys Res Commun (1994) 203: 141-8 [PMID:8074647]
GtoPdb	inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor	-	9.1	pKi	0.8	nM	Ki	Biochem Biophys Res Commun (1993) 193: 546-553 [PMID:8390245]
GtoPdb	cyclic AMP formation in HEK293 cells stably expressing recombinant receptor	-	9.7	pKi	0.2	nM	Ki	Biochem Biophys Res Commun (1994) 203: 141-8 [PMID:8074647]
GtoPdb	cyclic AMP formation in CHO cells stably expressing recombinant receptor	-	9.7	pKi	0.2	nM	Ki	Biochem Biophys Res Commun (1994) 203: 141-8 [PMID:8074647]
GtoPdb	inhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptor	-	9.8	pKi	0.16	nM	Ki	Biochem Biophys Res Commun (1994) 203: 141-8 [PMID:8074647]
GtoPdb	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	-	8	pIC50	10	nM	IC50	J Mol Neurosci (2002) 18: 29-35 [PMID:11931347]
GtoPdb	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	-	8.7	pIC50	2	nM	IC50	Eur J Pharmacol (1998) 354: 105-11 [PMID:9726637]
GtoPdb	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	-	8.7	pIC50	2	nM	IC50	Ann N Y Acad Sci (1998) 865: 247-52 [PMID:9928018]
GtoPdb	Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor	-	8.7	pIC50	2	nM	IC50	Peptides (1997) 18: 1539-45 [PMID:9437714]
GtoPdb	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	-	9.3	pIC50	0.5	nM	IC50	Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056]
GtoPdb	calcium influx in CHO cells stably expressing recombinant receptor	-	7.9	pEC50	14.1	nM	EC50	Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	-	8.5	pEC50	3	nM	EC50	J Mol Neurosci (2002) 18: 29-35 [PMID:11931347]
GtoPdb	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	-	8.9	pEC50	1.2	nM	EC50	J Pharmacol Exp Ther (1997) 281: 629-33 [PMID:9152366]
GtoPdb	cyclic AMP formation in CHO cells stably expressing recombinant receptor	-	9.3	pEC50	0.5	nM	EC50	Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056]
GtoPdb	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	-	9.4	pEC50	0.4	nM	EC50	J Biol Chem (2000) 275: 24003-12 [PMID:10801840]
GtoPdb	cyclic AMP formation in CHO cells stably expressing recombinant receptor	-	10	pEC50	0.11	nM	EC50	Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
VPAC1 receptor in Rat [GtoPdb: 371] [UniProtKB: P30083]
GtoPdb	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	-	8.7	pIC50	2	nM	IC50	Eur J Pharmacol (1998) 354: 105-11 [PMID:9726637]
GtoPdb	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	-	8.7	pIC50	2	nM	IC50	Peptides (1997) 18: 1539-45 [PMID:9437714]
GtoPdb	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	-	9	pIC50	1	nM	IC50	Ann N Y Acad Sci (1998) 865: 247-52 [PMID:9928018]
VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587]
GtoPdb	inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor	-	7.8	pKi	16	nM	Ki	J Pharmacol Exp Ther (1997) 281: 629-33 [PMID:9152366]
GtoPdb	inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor	-	8.7	pKi	1.8	nM	Ki	J Pharmacol Exp Ther (1998) 284: 744-50 [PMID:9454823]
GtoPdb	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	-	8.8	pKi	1.7	nM	Ki	J Biol Chem (2000) 275: 24003-12 [PMID:10801840]
GtoPdb	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	-	7.7	pIC50	20	nM	IC50	J Mol Neurosci (2002) 18: 29-35 [PMID:11931347]
GtoPdb	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	-	8	pIC50	10	nM	IC50	Eur J Pharmacol (1998) 354: 105-11 [PMID:9726637]
GtoPdb	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	-	8.3	pIC50	5	nM	IC50	Peptides (1997) 18: 1539-45 [PMID:9437714]
GtoPdb	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	-	8.5	pIC50	3	nM	IC50	Ann N Y Acad Sci (1998) 865: 247-52 [PMID:9928018]
GtoPdb	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	-	8.5	pIC50	3	nM	IC50	Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056]
GtoPdb	calcium influx in CHO cells stably expressing recombinant receptor	-	7.3	pEC50	50.9	nM	EC50	Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb	cyclic AMP formation in CHO cells stably expressing recombinant receptor	-	7.8	pEC50	15	nM	EC50	Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056]
GtoPdb	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	-	7.9	pEC50	14	nM	EC50	J Pharmacol Exp Ther (1997) 281: 629-33 [PMID:9152366]
GtoPdb	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	-	8.5	pEC50	3	nM	EC50	J Mol Neurosci (2002) 18: 29-35 [PMID:11931347]
GtoPdb	cyclic AMP formation in CHO cells stably expressing recombinant receptor	-	9.2	pEC50	0.63	nM	EC50	Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	-	9.3	pEC50	0.5	nM	EC50	J Biol Chem (2000) 275: 24003-12 [PMID:10801840]
VPAC2 receptor in Rat [GtoPdb: 372] [UniProtKB: P35000]
GtoPdb	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	-	8	pIC50	10	nM	IC50	Eur J Pharmacol (1998) 354: 105-11 [PMID:9726637]
GtoPdb	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	-	8.4	pIC50	4	nM	IC50	Ann N Y Acad Sci (1998) 865: 247-52 [PMID:9928018]
GtoPdb	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	-	8.4	pIC50	4	nM	IC50	Peptides (1997) 18: 1539-45 [PMID:9437714]