VIP [Ligand Id: 1152] activity data from GtoPdb

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  • secretin receptor in Human [GtoPdb: 252] [UniProtKB: P47872]
  • secretin receptor in Rat [GtoPdb: 252] [UniProtKB: P23811]
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  • PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586]
  • PAC1 receptor in Rat [GtoPdb: 370] [UniProtKB: P32215]
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  • VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241]
  • VPAC1 receptor in Rat [GtoPdb: 371] [UniProtKB: P30083]
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  • VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587]
  • VPAC2 receptor in Rat [GtoPdb: 372] [UniProtKB: P35000]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
secretin receptor in Human [GtoPdb: 252] [UniProtKB: P47872]
GtoPdb - - 5.4 pIC50 - - - EMBO J. (1991) 10: 1635-41 [PMID:1646711]
secretin receptor in Rat [GtoPdb: 252] [UniProtKB: P23811]
GtoPdb Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor - 6.2 pIC50 600 nM IC50 Peptides (1997) 18: 1539-45 [PMID:9437714]
PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586]
GtoPdb inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the PAC1 very short receptor - 6 pKi >1000 nM Ki J. Neuroendocrinol. (1999) 11: 941-9 [PMID:10583729]
GtoPdb inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the full length receptor (ENST00000304166) - 6.3 pKi 458 nM Ki J. Neuroendocrinol. (1999) 11: 941-9 [PMID:10583729]
GtoPdb inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the PAC1 short receptor (ENST00000409363) - 8.4 pKi 4.4 nM Ki J. Neuroendocrinol. (1999) 11: 941-9 [PMID:10583729]
GtoPdb inhibition of [125I]-PACAP-27 binding to membranes from NIH/3T3 cells stably expressing the recombinant receptor - 6 pIC50 >1000 nM IC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347]
GtoPdb stimulation of cyclic AMP formation in NIH/3T3 cells stably expressing the recombinant receptor - 6 pEC50 >1000 nM EC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347]
GtoPdb stimulation of cyclic AMP formation in HEK293 cells stably expressing the PAC1 very short receptor - 6.4 pEC50 373 nM EC50 J. Neuroendocrinol. (1999) 11: 941-9 [PMID:10583729]
GtoPdb calcium influx in CHO cells stably expressing recombinant receptor - 6.4 pEC50 389 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb stimulation of cyclic AMP formation in HEK293 cells stably expressing the full length receptor (ENST00000304166) - 6.7 pEC50 186 nM EC50 J. Neuroendocrinol. (1999) 11: 941-9 [PMID:10583729]
GtoPdb cyclic AMP formation in CHO cells stably expressing recombinant receptor - 7.8 pEC50 15.1 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb stimulation of cyclic AMP formation in HEK293 cells stably expressing the PAC1 short receptor (ENST00000409363) - 8.7 pEC50 2.1 nM EC50 J. Neuroendocrinol. (1999) 11: 941-9 [PMID:10583729]
PAC1 receptor in Rat [GtoPdb: 370] [UniProtKB: P32215]
GtoPdb inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the rat PAC1 receptor isoform including the hop1 exon - 5.5 pKi 3500 nM Ki Eur. J. Pharmacol. (1995) 288: 259-67 [PMID:7774670]
GtoPdb inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the rat PAC1 receptor isoform including the hop1 exon - 5.8 pKi 1500 nM Ki Eur. J. Pharmacol. (1995) 288: 259-67 [PMID:7774670]
GtoPdb Inhibition of [125I]-Ac-His1-PACAP-27 binding in membranes from CHO cells expressing recombinant receptor - 5.7 pIC50 2000 nM IC50 Peptides (1997) 18: 1539-45 [PMID:9437714]
GtoPdb stimulation of adenylate cyclase in CHO cells stably expressing the rat PAC1 receptor isoform including the hop1 exon - 7.1 pEC50 80 nM EC50 Eur. J. Pharmacol. (1995) 288: 259-67 [PMID:7774670]
GtoPdb stimulation of adenylate cyclase in CHO cells stably expressing the rat PAC1 receptor isoform lacking the hip and hop exons - 7.1 pEC50 80 nM EC50 Eur. J. Pharmacol. (1995) 288: 259-67 [PMID:7774670]
VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241]
GtoPdb inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor - 8.5 pKi 3.4 nM Ki J. Pharmacol. Exp. Ther. (1997) 281: 629-33 [PMID:9152366]
GtoPdb inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor - 8.9 pKi 1.4 nM Ki J. Pharmacol. Exp. Ther. (1998) 284: 744-50 [PMID:9454823]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 9 pKi 0.9 nM Ki J. Biol. Chem. (2000) 275: 24003-12 [PMID:10801840]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 9 pKi 0.9 nM Ki Eur. J. Pharmacol. (1996) 302: 207-14 [PMID:8791009]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 9.1 pKi 0.82 nM Ki Biochem. Biophys. Res. Commun. (1994) 203: 141-8 [PMID:8074647]
GtoPdb inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor - 9.1 pKi 0.8 nM Ki Biochem Biophys Res Commun (1993) 193: 546-553 [PMID:8390245]
GtoPdb cyclic AMP formation in HEK293 cells stably expressing recombinant receptor - 9.7 pKi 0.2 nM Ki Biochem. Biophys. Res. Commun. (1994) 203: 141-8 [PMID:8074647]
GtoPdb cyclic AMP formation in CHO cells stably expressing recombinant receptor - 9.7 pKi 0.2 nM Ki Biochem. Biophys. Res. Commun. (1994) 203: 141-8 [PMID:8074647]
GtoPdb inhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptor - 9.8 pKi 0.16 nM Ki Biochem. Biophys. Res. Commun. (1994) 203: 141-8 [PMID:8074647]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 8 pIC50 10 nM IC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347]
GtoPdb Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor - 8.7 pIC50 2 nM IC50 Peptides (1997) 18: 1539-45 [PMID:9437714]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 8.7 pIC50 2 nM IC50 Ann. N. Y. Acad. Sci. (1998) 865: 247-52 [PMID:9928018]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 8.7 pIC50 2 nM IC50 Eur. J. Pharmacol. (1998) 354: 105-11 [PMID:9726637]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 9.3 pIC50 0.5 nM IC50 Mol. Pharmacol. (1999) 56: 1280-7 [PMID:10570056]
GtoPdb calcium influx in CHO cells stably expressing recombinant receptor - 7.9 pEC50 14.1 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 8.5 pEC50 3 nM EC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 8.9 pEC50 1.2 nM EC50 J. Pharmacol. Exp. Ther. (1997) 281: 629-33 [PMID:9152366]
GtoPdb cyclic AMP formation in CHO cells stably expressing recombinant receptor - 9.3 pEC50 0.5 nM EC50 Mol. Pharmacol. (1999) 56: 1280-7 [PMID:10570056]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 9.4 pEC50 0.4 nM EC50 J. Biol. Chem. (2000) 275: 24003-12 [PMID:10801840]
GtoPdb cyclic AMP formation in CHO cells stably expressing recombinant receptor - 10 pEC50 0.11 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
VPAC1 receptor in Rat [GtoPdb: 371] [UniProtKB: P30083]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 8.7 pIC50 2 nM IC50 Eur. J. Pharmacol. (1998) 354: 105-11 [PMID:9726637]
GtoPdb Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor - 8.7 pIC50 2 nM IC50 Peptides (1997) 18: 1539-45 [PMID:9437714]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 9 pIC50 1 nM IC50 Ann. N. Y. Acad. Sci. (1998) 865: 247-52 [PMID:9928018]
VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587]
GtoPdb inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor - 7.8 pKi 16 nM Ki J. Pharmacol. Exp. Ther. (1997) 281: 629-33 [PMID:9152366]
GtoPdb inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor - 8.7 pKi 1.8 nM Ki J. Pharmacol. Exp. Ther. (1998) 284: 744-50 [PMID:9454823]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 8.8 pKi 1.7 nM Ki J. Biol. Chem. (2000) 275: 24003-12 [PMID:10801840]
GtoPdb inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor - 7.7 pIC50 20 nM IC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347]
GtoPdb inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor - 8 pIC50 10 nM IC50 Eur. J. Pharmacol. (1998) 354: 105-11 [PMID:9726637]
GtoPdb Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor - 8.3 pIC50 5 nM IC50 Peptides (1997) 18: 1539-45 [PMID:9437714]
GtoPdb inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor - 8.5 pIC50 3 nM IC50 Ann. N. Y. Acad. Sci. (1998) 865: 247-52 [PMID:9928018]
GtoPdb inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor - 8.5 pIC50 3 nM IC50 Mol. Pharmacol. (1999) 56: 1280-7 [PMID:10570056]
GtoPdb calcium influx in CHO cells stably expressing recombinant receptor - 7.3 pEC50 50.9 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb cyclic AMP formation in CHO cells stably expressing recombinant receptor - 7.8 pEC50 15 nM EC50 Mol. Pharmacol. (1999) 56: 1280-7 [PMID:10570056]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 7.9 pEC50 14 nM EC50 J. Pharmacol. Exp. Ther. (1997) 281: 629-33 [PMID:9152366]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 8.5 pEC50 3 nM EC50 J. Mol. Neurosci. (2002) 18: 29-35 [PMID:11931347]
GtoPdb cyclic AMP formation in CHO cells stably expressing recombinant receptor - 9.2 pEC50 0.63 nM EC50 Neuropharmacology (2006) 51: 1086-98 [PMID:16930633]
GtoPdb stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor - 9.3 pEC50 0.5 nM EC50 J. Biol. Chem. (2000) 275: 24003-12 [PMID:10801840]
VPAC2 receptor in Rat [GtoPdb: 372] [UniProtKB: P35000]
GtoPdb inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor - 8 pIC50 10 nM IC50 Eur. J. Pharmacol. (1998) 354: 105-11 [PMID:9726637]
GtoPdb inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor - 8.4 pIC50 4 nM IC50 Ann. N. Y. Acad. Sci. (1998) 865: 247-52 [PMID:9928018]
GtoPdb Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor - 8.4 pIC50 4 nM IC50 Peptides (1997) 18: 1539-45 [PMID:9437714]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.