DSM705 [Ligand Id: 11554] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| dihydroorotate dehydrogenase (quinone) in Human [GtoPdb: 2604] [UniProtKB: Q02127] | ||||||||
| GtoPdb | Steady-state kinetic analysis. | - | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2021) 64: 6085-6136 [PMID:33876936] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium berghei [GtoPdb: 2949] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (2021) 64: 6085-6136 [PMID:33876936] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949] | ||||||||
| GtoPdb | Steady-state kinetic analysis. | - | 7.02 | pIC50 | 95 | nM | IC50 | J Med Chem (2021) 64: 6085-6136 [PMID:33876936] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949] | ||||||||
| GtoPdb | Steady-state kinetic analysis. | - | 7.28 | pIC50 | 52 | nM | IC50 | J Med Chem (2021) 64: 6085-6136 [PMID:33876936] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.92 | pEC50 | 12 | nM | EC50 | J Med Chem (2021) 64: 6085-6136 [PMID:33876936] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
