analog 18 [PMID: 28696697] [Ligand Id: 11567] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4086345 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against stage V gametocytes of Plasmodium falciparum NF54 infected in human erythrocytes after 72 hrs by mitotracker red based bioluminescence assay | F | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
| ChEMBL | Potentiation of artemisinin-induced antimalarial activity against Plasmodium falciparum Dd2 assessed as artimisinin IC50 at 0.5 nM after 72 hrs by SYBR green dye based assay (Rvb = 19 +/- 0.6 nM) | F | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
| ChEMBL | Potentiation of artemisinin-induced antimalarial activity against Plasmodium falciparum Dd2 assessed as artimisinin IC50 at 1 nM after 72 hrs by SYBR green dye based assay (Rvb = 19 +/- 0.6 nM) | F | 8.12 | pIC50 | 7.5 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
| ChEMBL | Antimalarial activity against asexual blood stage Plasmodium falciparum Dd2 infected in human erythrocytes after 72 hrs by SYBR green 1 dye based fluorescence assay | F | 8.49 | pIC50 | 3.27 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
| Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum NF54 [GtoPdb: 3088] | ||||||||
| GtoPdb | Parasite late stage (V) gametocyte assay | - | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
| Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum Dd2 [GtoPdb: 3088] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 8.49 | pIC50 | 3.27 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
