CGP-37157 [Ligand Id: 11611] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1495071 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4693] [UniProtKB: P04191] | ||||||||
| ChEMBL | Inhibition of rabbit skeletal muscle microsomes SERCA1a | B | 5.18 | pIC50 | 6600 | nM | IC50 | J Med Chem (2020) 63: 1937-1963 [PMID:32030976] |
| Sodium/potassium/calcium exchanger 6/Sodium/potassium/calcium exchanger 6, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3763001] [GtoPdb: 1050] [UniProtKB: Q6J4K2] | ||||||||
| ChEMBL | Inhibition of mitochondrial sodium/calcium exchanger (unknown origin) | B | 5.8 | pIC50 | 1600 | nM | IC50 | Eur J Med Chem (2016) 109: 114-123 [PMID:26774037] |
| GtoPdb | - | - | 5.8 | pIC50 | 1600 | nM | IC50 | Eur J Med Chem (2016) 109: 114-23 [PMID:26774037] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
| ChEMBL | Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rat atrial myocytes | F | 6.57 | pIC50 | 270 | nM | IC50 | IC50 data for the L-type calcium channel extracted from a set of literature articles |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
