toceranib [Ligand Id: 11619] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL13608 (Palladia, PHA-291639, Toceranib) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Inhibition of epidermal growth factor receptor (EGF-R) | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
| fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
| GtoPdb | - | - | 6.3 | pKi | 500 | nM | Ki | Blood (2002) 100: 585-93 [PMID:12091352] |
| ChEMBL | Inhibition of Fibroblast growth factor receptor 1 | B | 5.41 | pIC50 | 3900 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
| platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha in Human [GtoPdb: 1804, 1803] [UniProtKB: P09619, P16234] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | 5 | nM | Ki | Blood (2002) 100: 585-93 [PMID:12091352] |
| platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Mouse (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096980] [GtoPdb: 1804, 1803] [UniProtKB: P05622, P26618] | ||||||||
| ChEMBL | Inhibition of Platelet-derived growth factor induced 3T3 cell proliferation | F | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
| ChEMBL | Inhibition of PDGF-induced BrdU incorporation in 3T3 cells | F | 7.15 | pIC50 | <70 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Inhibition of Platelet-derived growth factor receptor beta (PDGF-Rbeta) | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| GtoPdb | - | - | 8.22 | pKi | 6 | nM | Ki | Blood (2002) 100: 585-93 [PMID:12091352] |
| ChEMBL | Inhibition of Vascular endothelial growth factor receptor 2 | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2003) 46: 1116-1119 [PMID:12646019] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
