[3H]alniditan [Ligand Id: 117] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL88240 (Alniditan)
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Ability to bind to 5-hydroxytryptamine 1A receptor from cloned human expressed in Ha7 cells B 8.3 pIC50 5.01 nM IC50 Bioorg Med Chem Lett (1995) 5: 2649-2654
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 8.92 pKd 1.2 nM Kd Br J Pharmacol (1998) 123: 1655-65 [PMID:9605573]
ChEMBL Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra B 8.6 pIC50 2.51 nM IC50 Bioorg Med Chem Lett (1995) 5: 2649-2654
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 9 pKd 1 nM Kd Br J Pharmacol (1998) 123: 1655-65 [PMID:9605573]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]