[3H]alniditan [Ligand Id: 117] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL88240 (Alniditan)
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Ability to bind to 5-hydroxytryptamine 1A receptor from cloned human expressed in Ha7 cells B 8.3 pIC50 5.01 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 2649-2654
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 8.92 pKd 1.2 nM Kd Br. J. Pharmacol. (1998) 123: 1655-65 [PMID:9605573]
ChEMBL Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra B 8.6 pIC50 2.51 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 2649-2654
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 9 pKd 1 nM Kd Br. J. Pharmacol. (1998) 123: 1655-65 [PMID:9605573]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]