maralixibat [Ligand Id: 11708] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL363392 (Lopixibat, LUM-001 CATION, LUM001 CATION, Maralixibat, Maralixibat cation) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908] | ||||||||
| GtoPdb | In vitro inhibition of [14C]taurocholate uptake via hASBT expressed in BHK cells. | - | 9.55 | pIC50 | 0.28 | nM | IC50 | J Med Chem (2005) 48: 5853-68 [PMID:16134951] |
| ChEMBL | In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | B | 9.55 | pIC50 | 0.28 | nM | IC50 | J Med Chem (2005) 48: 5853-5868 [PMID:16134951] |
| ChEMBL | Inhibition of human IBAT | B | 9.55 | pIC50 | 0.28 | nM | IC50 | ACS Med Chem Lett (2023) 14: 233-243 [PMID:36923921] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
