maralixibat [Ligand Id: 11708] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL363392 (Lopixibat, LUM-001 CATION, LUM001 CATION, Maralixibat, Maralixibat cation) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908] | ||||||||
| GtoPdb | In vitro inhibition of [14C]taurocholate uptake via hASBT expressed in BHK cells. | - | 9.55 | pIC50 | 0.28 | nM | IC50 | J Med Chem (2005) 48: 5853-68 [PMID:16134951] |
| ChEMBL | In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | B | 9.55 | pIC50 | 0.28 | nM | IC50 | J Med Chem (2005) 48: 5853-5868 [PMID:16134951] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
