MD-222 [Ligand Id: 11725] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4436772 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cereblon/Protein cereblon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3763008] [GtoPdb: 3086] [UniProtKB: Q96SW2] | ||||||||
| GtoPdb | - | - | 8 | pIC50 | >10 | nM | IC50 | J Med Chem (2019) 62: 9471-9487 [PMID:31560543] |
| ChEMBL | Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as cell growth inhibition measured after 4 days | B | 8 | pIC50 | >10 | nM | IC50 | J Med Chem (2019) 62: 9471-9487 [PMID:31560543] |
| ChEMBL | Binding affinity to cereblon in human MDA-MB-231 cells assessed as cell growth inhibition measured after 4 days | B | 8 | pIC50 | >10 | nM | IC50 | J Med Chem (2019) 62: 9471-9487 [PMID:31560543] |
| ChEMBL | Binding affinity to cereblon in human MDA-MB-468 cells assessed as cell growth inhibition measured after 4 days | B | 8 | pIC50 | >10 | nM | IC50 | J Med Chem (2019) 62: 9471-9487 [PMID:31560543] |
| ChEMBL | Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as cell growth inhibition measured after 4 days | B | 8.26 | pIC50 | 5.5 | nM | IC50 | J Med Chem (2019) 62: 9471-9487 [PMID:31560543] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
