MD-222 [Ligand Id: 11725] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4436772 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cereblon/Protein cereblon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3763008] [GtoPdb: 3086] [UniProtKB: Q96SW2] | ||||||||
| GtoPdb | - | - | 8 | pIC50 | >10 | nM | IC50 | J Med Chem (2019) 62: 9471-9487 [PMID:31560543] |
| ChEMBL | Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as cell growth inhibition measured after 4 days | B | 8 | pIC50 | >10 | nM | IC50 | J Med Chem (2019) 62: 9471-9487 [PMID:31560543] |
| ChEMBL | Binding affinity to cereblon in human MDA-MB-231 cells assessed as cell growth inhibition measured after 4 days | B | 8 | pIC50 | >10 | nM | IC50 | J Med Chem (2019) 62: 9471-9487 [PMID:31560543] |
| ChEMBL | Binding affinity to cereblon in human MDA-MB-468 cells assessed as cell growth inhibition measured after 4 days | B | 8 | pIC50 | >10 | nM | IC50 | J Med Chem (2019) 62: 9471-9487 [PMID:31560543] |
| ChEMBL | Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as cell growth inhibition measured after 4 days | B | 8.26 | pIC50 | 5.5 | nM | IC50 | J Med Chem (2019) 62: 9471-9487 [PMID:31560543] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
