AIM-1290 [Ligand Id: 11823] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4872683 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium falciparum infected in human RBC assessed as reduction in parasite growth measured after 72 hrs by flow cytometry analysis | F | 7.13 | pIC50 | 74 | nM | IC50 | Bioorg Med Chem Lett (2021) 41: 127978-127978 [PMID:33766764] |
| Plasmodium falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase in Plasmodium falciparum [GtoPdb: 3173] | ||||||||
| GtoPdb | - | - | 5.71 | pIC50 | 1940 | nM | IC50 | Bioorg Med Chem Lett (2021) 41: 127978 [PMID:33766764] |
| GtoPdb | Parasite growth inhibition assay | - | 7.13 | pIC50 | 74 | nM | IC50 | Bioorg Med Chem Lett (2021) 41: 127978 [PMID:33766764] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
