BOP [Ligand Id: 12045] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL288474 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)/Integrin alpha-4/beta-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907599] [GtoPdb: 2455, 2443] [UniProtKB: P05556, P13612] | ||||||||
| ChEMBL | Alpha4-beta1 integrin binding affinity was assessed by measuring the reduction in binding of [125I]VCAM-Ig to a suspension of Jurkat cells (a human T cell line alpha-4-beta-1-beta-7) | B | 9.85 | pIC50 | 0.14 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 159-163 [PMID:11755344] |
| integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)/integrin, beta 7 subunit/Integrin alpha-4/beta-7 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095184] [GtoPdb: 2443, 2461] [UniProtKB: P13612, P26010] | ||||||||
| ChEMBL | Alpha4-beta7 integrin binding affinity was determined in duplicate by a radioligand binding assay using [125I]-VCAM-Ig and a suspension of RPMI-8866 cells (a human B cell line alpha-4-beta-1-beta-7+) | B | 8.55 | pIC50 | 2.83 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 159-163 [PMID:11755344] |
| integrin, alpha 9 subunit in Human [GtoPdb: 2448] [UniProtKB: Q13797] | ||||||||
| GtoPdb | Binding affinity for α9β1 intergrin in vitro | - | 11.52 | pKd | 0 | nM | Kd | Biochemistry (2002) 41: 7125-41 [PMID:12033947] |
| integrin α4β1 in Human [GtoPdb: 2580] | ||||||||
| GtoPdb | - | - | 11.3 | pKd | 0 | nM | Kd | Biochemistry (2002) 41: 7125-41 [PMID:12033947] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
