CP-640186 [Ligand Id: 12243] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL208943 (CP-640186)
There should be some charts here, you may need to enable JavaScript!
  • Acetyl-CoA carboxylase 2 in Human [ChEMBL: CHEMBL4829] [GtoPdb: 1264] [UniProtKB: O00763]
  • Acetyl-CoA carboxylase 2 in Rat [GtoPdb: 1264]
There should be some charts here, you may need to enable JavaScript!
  • Acetyl-Coenzyme A carboxylase 2 in Rat [ChEMBL: CHEMBL5125] [UniProtKB: Q1HEC0]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetyl-CoA carboxylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3351] [GtoPdb: 1263] [UniProtKB: Q13085]
ChEMBL Inhibition of N-terminal His-tagged human recombinant ACC1 expressed in high five insect cells by ATP consumption assay B 6.04 pIC50 910 nM IC50 J Med Chem (2010) 53: 8679-8687 [PMID:21082864]
ChEMBL Inhibition of human ACC1 B 6.26 pIC50 550 nM IC50 Bioorg Med Chem Lett (2011) 21: 6314-6318 [PMID:21944854]
ChEMBL Inhibition of human recombinant ACC1 B 6.34 pIC50 456 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443]
ChEMBL Inhibition of human recombinant ACC1 expressed in HEK293 cells B 6.39 pIC50 410 nM IC50 J Med Chem (2006) 49: 3770-3773 [PMID:16789734]
ChEMBL Inhibition of human recombinant ACC1 B 6.39 pIC50 410 nM IC50 Bioorg Med Chem Lett (2006) 16: 6078-6081 [PMID:16973360]
GtoPdb - - 6.39 pIC50 410 nM IC50 Bioorg Med Chem Lett (2006) 16: 6078-81 [PMID:16973360]
Acetyl-CoA carboxylase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2397] [GtoPdb: 1263] [UniProtKB: P11497]
ChEMBL Inhibition of N-terminal His-tagged rat recombinant ACC1 expressed in high five insect cells by ATP consumption assay B 6.23 pIC50 590 nM IC50 J Med Chem (2010) 53: 8679-8687 [PMID:21082864]
ChEMBL Inhibition of obese Zucker rat ACC1 assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malachite green reagent method B 6.64 pIC50 230 nM IC50 Bioorg Med Chem (2011) 19: 3039-3053 [PMID:21515056]
ChEMBL Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter B 7.04 pIC50 92 nM IC50 Bioorg Med Chem Lett (2010) 20: 2383-2388 [PMID:20219367]
ChEMBL Inhibition of rat acetyl-CoA carboxylase 1 B 7.26 pIC50 55 nM IC50 Bioorg Med Chem Lett (2009) 19: 949-953 [PMID:19097787]
ChEMBL Inhibitory activity against rat ACC1 B 7.28 pIC50 53 nM IC50 J Med Chem (2006) 49: 3770-3773 [PMID:16789734]
ChEMBL Inhibition of rat ACC1 B 7.28 pIC50 53 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443]
GtoPdb - - 7.28 pIC50 53 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-8 [PMID:19853443]
Acetyl-CoA carboxylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4829] [GtoPdb: 1264] [UniProtKB: O00763]
ChEMBL Inhibition of human recombinant ACC2 B 6.71 pIC50 194 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443]
ChEMBL Inhibition of N-terminal His-tagged human recombinant ACC2 expressed in high five insect cells by ATP consumption assay B 7.15 pIC50 70 nM IC50 J Med Chem (2010) 53: 8679-8687 [PMID:21082864]
ChEMBL Inhibitory activity against rat ACC2 B 7.21 pIC50 61 nM IC50 J Med Chem (2006) 49: 3770-3773 [PMID:16789734]
GtoPdb - - 7.42 pIC50 38 nM IC50 Bioorg Med Chem Lett (2006) 16: 6078-81 [PMID:16973360]
ChEMBL Inhibition of human recombinant ACC2 expressed in baculovirus/sf9 system B 7.42 pIC50 38 nM IC50 J Med Chem (2006) 49: 3770-3773 [PMID:16789734]
ChEMBL Inhibition of human recombinant ACC2 B 7.42 pIC50 38 nM IC50 Bioorg Med Chem Lett (2006) 16: 6078-6081 [PMID:16973360]
ChEMBL Inhibition of human ACC2 B 7.47 pIC50 34 nM IC50 Bioorg Med Chem Lett (2011) 21: 6314-6318 [PMID:21944854]
Acetyl-CoA carboxylase 2 in Rat [GtoPdb: 1264]
GtoPdb - - 7.21 pIC50 61 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-8 [PMID:19853443]
Acetyl-Coenzyme A carboxylase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5125] [UniProtKB: Q1HEC0]
ChEMBL Inhibition of ACC2 in obese Zucker rat assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malachite green reagent method B 6.77 pIC50 170 nM IC50 Bioorg Med Chem (2011) 19: 3039-3053 [PMID:21515056]
ChEMBL Inhibition of rat ACC2 B 7.21 pIC50 61 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443]
ChEMBL Inhibition of rat acetyl-CoA carboxylase 2 B 7.26 pIC50 55 nM IC50 Bioorg Med Chem Lett (2009) 19: 949-953 [PMID:19097787]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]