CP-640186 [Ligand Id: 12243] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL208943 (CP-640186)
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  • Acetyl-CoA carboxylase 2 in Human [ChEMBL: CHEMBL4829] [GtoPdb: 1264] [UniProtKB: O00763]
  • Acetyl-CoA carboxylase 2 in Rat [GtoPdb: 1264]
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  • Acetyl-Coenzyme A carboxylase 2 in Rat [ChEMBL: CHEMBL5125] [UniProtKB: Q1HEC0]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetyl-CoA carboxylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3351] [GtoPdb: 1263] [UniProtKB: Q13085]
ChEMBL Inhibition of N-terminal His-tagged human recombinant ACC1 expressed in high five insect cells by ATP consumption assay B 6.04 pIC50 910 nM IC50 J Med Chem (2010) 53: 8679-8687 [PMID:21082864]
ChEMBL Inhibition of human ACC1 B 6.26 pIC50 550 nM IC50 Bioorg Med Chem Lett (2011) 21: 6314-6318 [PMID:21944854]
ChEMBL Inhibition of human recombinant ACC1 B 6.34 pIC50 456 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443]
ChEMBL Inhibition of human recombinant ACC1 expressed in HEK293 cells B 6.39 pIC50 410 nM IC50 J Med Chem (2006) 49: 3770-3773 [PMID:16789734]
ChEMBL Inhibition of human recombinant ACC1 B 6.39 pIC50 410 nM IC50 Bioorg Med Chem Lett (2006) 16: 6078-6081 [PMID:16973360]
GtoPdb - - 6.39 pIC50 410 nM IC50 Bioorg Med Chem Lett (2006) 16: 6078-81 [PMID:16973360]
Acetyl-CoA carboxylase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2397] [GtoPdb: 1263] [UniProtKB: P11497]
ChEMBL Inhibition of N-terminal His-tagged rat recombinant ACC1 expressed in high five insect cells by ATP consumption assay B 6.23 pIC50 590 nM IC50 J Med Chem (2010) 53: 8679-8687 [PMID:21082864]
ChEMBL Inhibition of obese Zucker rat ACC1 assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malachite green reagent method B 6.64 pIC50 230 nM IC50 Bioorg Med Chem (2011) 19: 3039-3053 [PMID:21515056]
ChEMBL Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter B 7.04 pIC50 92 nM IC50 Bioorg Med Chem Lett (2010) 20: 2383-2388 [PMID:20219367]
ChEMBL Inhibition of rat acetyl-CoA carboxylase 1 B 7.26 pIC50 55 nM IC50 Bioorg Med Chem Lett (2009) 19: 949-953 [PMID:19097787]
ChEMBL Inhibitory activity against rat ACC1 B 7.28 pIC50 53 nM IC50 J Med Chem (2006) 49: 3770-3773 [PMID:16789734]
ChEMBL Inhibition of rat ACC1 B 7.28 pIC50 53 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443]
GtoPdb - - 7.28 pIC50 53 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-8 [PMID:19853443]
Acetyl-CoA carboxylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4829] [GtoPdb: 1264] [UniProtKB: O00763]
ChEMBL Inhibition of human recombinant ACC2 B 6.71 pIC50 194 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443]
ChEMBL Inhibition of N-terminal His-tagged human recombinant ACC2 expressed in high five insect cells by ATP consumption assay B 7.15 pIC50 70 nM IC50 J Med Chem (2010) 53: 8679-8687 [PMID:21082864]
ChEMBL Inhibitory activity against rat ACC2 B 7.21 pIC50 61 nM IC50 J Med Chem (2006) 49: 3770-3773 [PMID:16789734]
GtoPdb - - 7.42 pIC50 38 nM IC50 Bioorg Med Chem Lett (2006) 16: 6078-81 [PMID:16973360]
ChEMBL Inhibition of human recombinant ACC2 expressed in baculovirus/sf9 system B 7.42 pIC50 38 nM IC50 J Med Chem (2006) 49: 3770-3773 [PMID:16789734]
ChEMBL Inhibition of human recombinant ACC2 B 7.42 pIC50 38 nM IC50 Bioorg Med Chem Lett (2006) 16: 6078-6081 [PMID:16973360]
ChEMBL Inhibition of human ACC2 B 7.47 pIC50 34 nM IC50 Bioorg Med Chem Lett (2011) 21: 6314-6318 [PMID:21944854]
Acetyl-CoA carboxylase 2 in Rat [GtoPdb: 1264]
GtoPdb - - 7.21 pIC50 61 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-8 [PMID:19853443]
Acetyl-Coenzyme A carboxylase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5125] [UniProtKB: Q1HEC0]
ChEMBL Inhibition of ACC2 in obese Zucker rat assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malachite green reagent method B 6.77 pIC50 170 nM IC50 Bioorg Med Chem (2011) 19: 3039-3053 [PMID:21515056]
ChEMBL Inhibition of rat ACC2 B 7.21 pIC50 61 nM IC50 Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443]
ChEMBL Inhibition of rat acetyl-CoA carboxylase 2 B 7.26 pIC50 55 nM IC50 Bioorg Med Chem Lett (2009) 19: 949-953 [PMID:19097787]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]