ranitidine [Ligand Id: 1234] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL512
  • H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
  • H2 receptor in Rat [GtoPdb: 263] [UniProtKB: P25102]
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  • Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL Antagonist activity at histamine H2 receptor (unknown origin) assessed as inhibition constant B 7.05 pKi 89 nM Ki J Med Chem (2021) 64: 1786-1815 [PMID:33569941]
GtoPdb - - 7.1 pKi 79.4 nM Ki Br J Pharmacol (1994) 112: 847-54 [PMID:7921611]
H2 receptor in Rat [GtoPdb: 263] [UniProtKB: P25102]
GtoPdb - - 6.2 pKi 631 nM Ki Br J Pharmacol (1997) 122: 867-74 [PMID:9384502]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL Inhibition of OCT1(unknown origin)-mediated ASP+ uptake in HEK293 cells expressing OCT1 using ASP+ as substrate incubated for 5 mins B 4.55 pIC50 28000 nM IC50 J Nat Prod (2023) 86: 191-198 [PMID:36563333]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]