N-[3H]methylhistamine [Ligand Id: 1241] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL507 (N-Methylhistamine)
  • H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
  • H3 receptor in Rat [GtoPdb: 264] [UniProtKB: Q9QYN8]
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  • H4 receptor/Histamine H4 receptor in Human [ChEMBL: CHEMBL3759] [GtoPdb: 265] [UniProtKB: Q9H3N8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
GtoPdb - - 9.1 pKd - - - Mol. Pharmacol. (2001) 59: 420-6 [PMID:11179434]
ChEMBL Binding affinity to histamine H3 receptor (unknown origin) B 4.7 pKi 20000 nM Ki Bioorg Med Chem Lett (2016) 26: 5263-5266 [PMID:27692832]
H3 receptor in Rat [GtoPdb: 264] [UniProtKB: Q9QYN8]
GtoPdb - - 9.1 pKd - - - J. Pharmacol. Exp. Ther. (2000) 293: 771-8 [PMID:10869375]
H4 receptor/Histamine H4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3759] [GtoPdb: 265] [UniProtKB: Q9H3N8]
GtoPdb - - 7.8 pKd - - - Mol. Pharmacol. (2001) 59: 420-6 [PMID:11179434]
ChEMBL Binding affinity to histamine H4 receptor (unknown origin) B 4.96 pKi 11000 nM Ki Bioorg Med Chem Lett (2016) 26: 5263-5266 [PMID:27692832]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]