ChEMBL ligand: CHEMBL4789639 (Bms-986202, BMS986202)
Janus kinase 1/Janus kinase 3/JAK3/JAK1 in Human [ChEMBL: CHEMBL3038491] [GtoPdb: 2047, 2049] [UniProtKB: P23458, P52333] There should be some charts here, you may need to enable JavaScript!
tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597] tyrosine kinase 2/Non-receptor tyrosine-protein kinase TYK2 in Mouse [ChEMBL: CHEMBL2321619] [GtoPdb: 2269] [UniProtKB: Q9R117] There should be some charts here, you may need to enable JavaScript!
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] There should be some charts here, you may need to enable JavaScript!
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] There should be some charts here, you may need to enable JavaScript!
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Janus kinase 1/Janus kinase 3/JAK3/JAK1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038491] [GtoPdb: 2047, 2049] [UniProtKB: P23458, P52333]
ChEMBL	Inhibition of JAK1/3 (unknown origin) by IL-2 dependent cell based assay	B	4.9	pIC50	>12500	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597]
GtoPdb	Binding affinity for Tyk2 JH2 domain	-	10.7	pKi	0.02	nM	Ki	J Med Chem (2021) 64: 677-694 [PMID:33370104]
GtoPdb	-	-	9.72	pIC50	0.19	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
tyrosine kinase 2/Non-receptor tyrosine-protein kinase TYK2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321619] [GtoPdb: 2269] [UniProtKB: Q9R117]
ChEMBL	Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylation	B	6.32	pIC50	481	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
ChEMBL	Inhibition of JAK1 JH2 domain (unknown origin)	B	8.11	pIC50	7.8	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL	Inhibition of JAK2 (unknown origin) by EPO-stimulated cell based assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597]
ChEMBL	Inhibition of TYK2 JH2 domain (unknown origin) by HTRF assay based Morrison titration analysis	B	10.7	pKi	0.02	nM	Ki	J Med Chem (2021) 64: 677-694 [PMID:33370104]
GtoPdb	Binding affinity for Tyk2 JH2 domain	-	10.7	pKi	0.02	nM	Ki	J Med Chem (2021) 64: 677-694 [PMID:33370104]
ChEMBL	Inhibition of TYK2 in human whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylation	B	7.24	pIC50	58	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
ChEMBL	Inhibition of TYK2 in IL-23 stimulated human Kit225 T cells by luciferase reporter gene assay	B	7.92	pIC50	12	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
ChEMBL	Inhibition of TYK2 in IFN-alpha stimulated human Kit225 T cells by luciferase reporter gene assay	B	8	pIC50	10	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
GtoPdb	-	-	9.72	pIC50	0.19	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]
ChEMBL	Inhibition of TYK2 JH2 domain (unknown origin) by HTRF assay	B	9.72	pIC50	0.19	nM	IC50	J Med Chem (2021) 64: 677-694 [PMID:33370104]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]