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ChEMBL ligand: CHEMBL4452527 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Signal transducer and activator of transcription 1-alpha/beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6101] [UniProtKB: P42224] | ||||||||
ChEMBL | Binding affinity to recombinant human His/SUMO-tagged STAT1 (132 to 713 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay | B | 6 | pKd | 1000 | nM | Kd | J Med Chem (2019) 62: 11280-11300 [PMID:31747516] |
ChEMBL | Binding affinity to His-tagged human STAT1 (132 to 713 residues) expressed in Escherichia coli Rosette (DE3) assessed as dissociation constant using SD-45-FL as substrate measured after 1 hr by Fluorescence Polarization assay | B | 6 | pKd | 1000 | nM | Kd | J Med Chem (2022) 65: 8113-8126 [PMID:35658428] |
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763] | ||||||||
ChEMBL | Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay | B | 7.36 | pKd | 44 | nM | Kd | J Med Chem (2019) 62: 11280-11300 [PMID:31747516] |
ChEMBL | Binding affinity to His-SUMO-tagged human STAT3 (127 to 688 residues) expressed in Escherichia coli Rosette (DE3) assessed as dissociation constant using SD-45-FL as substrate measured after 1 hr by Fluorescence Polarization assay | B | 7.36 | pKd | 44 | nM | Kd | J Med Chem (2022) 65: 8113-8126 [PMID:35658428] |
GtoPdb | Binding affinity for hSTAT3, determined by fluorescence polarization assay | - | 7.36 | pKd | 44 | nM | Kd | J Med Chem (2019) 62: 11280-11300 [PMID:31747516] |
ChEMBL | Binding affinity to recombinant STAT3 (unknown origin) assessed as inhibition constant incubated for 1 hr by fluorescence polarization assay | B | 7.93 | pKi | 11.7 | nM | Ki | ACS Med Chem Lett (2021) 12: 996-1004 [PMID:34141084] |
Signal transducer and activator of transcription 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523296] [UniProtKB: Q14765] | ||||||||
ChEMBL | Binding affinity to recombinant human His/SUMO-tagged STAT4 (133 to 705 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay | B | 6 | pKd | 1000 | nM | Kd | J Med Chem (2019) 62: 11280-11300 [PMID:31747516] |
ChEMBL | Binding affinity to His-MBP-tagged human STAT4 (133 to 705 residues) expressed in Escherichia coli Rosette (DE3) assessed as dissociation constant using SD-45-FL as substrate measured after 1 hr by Fluorescence Polarization assay | B | 6 | pKd | 1000 | nM | Kd | J Med Chem (2022) 65: 8113-8126 [PMID:35658428] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]