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ChEMBL ligand: CHEMBL4452527 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Signal transducer and activator of transcription 1-alpha/beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6101] [UniProtKB: P42224] | ||||||||
ChEMBL | Binding affinity to recombinant human His/SUMO-tagged STAT1 (132 to 713 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay | B | 6 | pKd | 1000 | nM | Kd | J Med Chem (2019) 62: 11280-11300 [PMID:31747516] |
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763] | ||||||||
ChEMBL | Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay | B | 7.36 | pKd | 44 | nM | Kd | J Med Chem (2019) 62: 11280-11300 [PMID:31747516] |
GtoPdb | Binding affinity for hSTAT3, determined by fluorescence polarization assay | - | 7.36 | pKd | 44 | nM | Kd | J Med Chem (2019) 62: 11280-11300 [PMID:31747516] |
ChEMBL | Binding affinity to recombinant STAT3 (unknown origin) assessed as inhibition constant incubated for 1 hr by fluorescence polarization assay | B | 7.93 | pKi | 11.7 | nM | Ki | ACS Med Chem Lett (2021) 12: 996-1004 [PMID:34141084] |
Signal transducer and activator of transcription 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523296] [UniProtKB: Q14765] | ||||||||
ChEMBL | Binding affinity to recombinant human His/SUMO-tagged STAT4 (133 to 705 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay | B | 6 | pKd | 1000 | nM | Kd | J Med Chem (2019) 62: 11280-11300 [PMID:31747516] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]