ChEMBL ligand: CHEMBL4452527
Signal transducer and activator of transcription 1-alpha/beta in Human [ChEMBL: CHEMBL6101] [UniProtKB: P42224] There should be some charts here, you may need to enable JavaScript!
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763] There should be some charts here, you may need to enable JavaScript!
Signal transducer and activator of transcription 4 in Human [ChEMBL: CHEMBL4523296] [UniProtKB: Q14765] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Signal transducer and activator of transcription 1-alpha/beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6101] [UniProtKB: P42224]
ChEMBL	Binding affinity to recombinant human His/SUMO-tagged STAT1 (132 to 713 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay	B	6	pKd	1000	nM	Kd	J Med Chem (2019) 62: 11280-11300 [PMID:31747516]
ChEMBL	Binding affinity to His-tagged human STAT1 (132 to 713 residues) expressed in Escherichia coli Rosette (DE3) assessed as dissociation constant using SD-45-FL as substrate measured after 1 hr by Fluorescence Polarization assay	B	6	pKd	1000	nM	Kd	J Med Chem (2022) 65: 8113-8126 [PMID:35658428]
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763]
ChEMBL	Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay	B	7.36	pKd	44	nM	Kd	J Med Chem (2019) 62: 11280-11300 [PMID:31747516]
ChEMBL	Binding affinity to His-SUMO-tagged human STAT3 (127 to 688 residues) expressed in Escherichia coli Rosette (DE3) assessed as dissociation constant using SD-45-FL as substrate measured after 1 hr by Fluorescence Polarization assay	B	7.36	pKd	44	nM	Kd	J Med Chem (2022) 65: 8113-8126 [PMID:35658428]
GtoPdb	Binding affinity for hSTAT3, determined by fluorescence polarization assay	-	7.36	pKd	44	nM	Kd	J Med Chem (2019) 62: 11280-11300 [PMID:31747516]
ChEMBL	Binding affinity to recombinant STAT3 (unknown origin) assessed as inhibition constant incubated for 1 hr by fluorescence polarization assay	B	7.93	pKi	11.7	nM	Ki	ACS Med Chem Lett (2021) 12: 996-1004 [PMID:34141084]
Signal transducer and activator of transcription 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523296] [UniProtKB: Q14765]
ChEMBL	Binding affinity to recombinant human His/SUMO-tagged STAT4 (133 to 705 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay	B	6	pKd	1000	nM	Kd	J Med Chem (2019) 62: 11280-11300 [PMID:31747516]
ChEMBL	Binding affinity to His-MBP-tagged human STAT4 (133 to 705 residues) expressed in Escherichia coli Rosette (DE3) assessed as dissociation constant using SD-45-FL as substrate measured after 1 hr by Fluorescence Polarization assay	B	6	pKd	1000	nM	Kd	J Med Chem (2022) 65: 8113-8126 [PMID:35658428]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]