mescaline [Ligand Id: 13139] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL26687 (2-(3,4,5-Trimethoxyphenyl)Ethanamine, Mescaline, NSC-30419) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Ability to displace [3H]-8-OH-DPAT from rat hippocampal homogenate 5-hydroxytryptamine 1A receptor | B | 5.16 | pKi | 6900 | nM | Ki | J Med Chem (1997) 40: 2997-3008 [PMID:9301661] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Agonist activity at cloned human 5-hydroxytryptamine 2A receptor using [125I]DOI radioligand | F | 6.26 | pKi | 551 | nM | Ki | J Med Chem (1997) 40: 2997-3008 [PMID:9301661] |
| GtoPdb | Potency determined in an IP3 accumulation assay | - | 5.59 | pEC50 | 2600 | nM | EC50 | J Med Chem (2003) 46: 3526-35 [PMID:12877591] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| ChEMBL | Ability to displace [3H]ketanserin from rat cortical homogenate 5-hydroxytryptamine 2A receptor | B | 5.26 | pKi | 5500 | nM | Ki | J Med Chem (1997) 40: 2997-3008 [PMID:9301661] |
| ChEMBL | Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopy | B | 5.26 | pKi | 5500 | nM | Ki | Bioorg Med Chem (2008) 16: 4661-4669 [PMID:18296055] |
| ChEMBL | Displacement of [125I]DOI from rat 5HT2A receptor | B | 6.44 | pKi | 360 | nM | Ki | J Med Chem (2006) 49: 4269-4274 [PMID:16821786] |
| ChEMBL | Activity at rat 5HT2A receptor assessed as 5-HT-stimulated IP3 accumulation | F | 4.95 | pEC50 | 11300 | nM | EC50 | J Med Chem (2006) 49: 4269-4274 [PMID:16821786] |
| ChEMBL | Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2A receptor | F | 5.4 | pEC50 | 4000 | nM | EC50 | J Med Chem (1997) 40: 2997-3008 [PMID:9301661] |
| ChEMBL | Tested for its ability to activate phospholipase c by quantification of IP3 at cloned rat 5-hydroxytryptamine 2A receptor | B | 5.59 | pEC50 | 2600 | nM | EC50 | J Med Chem (2003) 46: 3526-3535 [PMID:12877591] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand | F | 6.1 | pKi | 795.1 | nM | Ki | J Med Chem (1997) 40: 2997-3008 [PMID:9301661] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Agonist activity at cloned human 5-hydroxytryptamine 2C receptor using [125I]DOI radioligand | F | 6.52 | pKi | 302.8 | nM | Ki | J Med Chem (1997) 40: 2997-3008 [PMID:9301661] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909] | ||||||||
| ChEMBL | Displacement of [125I]DOI from rat 5HT2C receptor | B | 6.42 | pKi | 380 | nM | Ki | J Med Chem (2006) 49: 4269-4274 [PMID:16821786] |
| ChEMBL | Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor | F | 4.62 | pEC50 | 24000 | nM | EC50 | J Med Chem (1997) 40: 2997-3008 [PMID:9301661] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
