brimarafenib [Ligand Id: 13203] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B-Raf proto-oncogene, serine/threonine kinase in Human [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
| GtoPdb | Inhibition of WT BRAF | - | 8.1 | pIC50 | 7.9 | nM | IC50 | WO2014206343A1. Fused tricyclic urea compounds as raf kinase and/or raf kinase dimer inhibitors (2014) |
| GtoPdb | Inhibition of BRAFV600E | - | 8.92 | pIC50 | 1.2 | nM | IC50 | WO2014206343A1. Fused tricyclic urea compounds as raf kinase and/or raf kinase dimer inhibitors (2014) |
| Raf-1 proto-oncogene, serine/threonine kinase in Human [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| GtoPdb | Inhibition of WT CRAF | - | 9.72 | pIC50 | 0.19 | nM | IC50 | WO2014206343A1. Fused tricyclic urea compounds as raf kinase and/or raf kinase dimer inhibitors (2014) |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
