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ChEMBL ligand: CHEMBL289233 (2-Iodomelatonin, Iodomelatonin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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MT1 receptor/Melatonin receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039] | ||||||||
ChEMBL | Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells | B | 10.1 | pKi | 0.08 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 2409-2414 |
ChEMBL | Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells | B | 10.17 | pKi | 0.07 | nM | Ki | J Med Chem (2014) 57: 3161-3185 [PMID:24228714] |
ChEMBL | Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells | B | 10.89 | pKi | 0.01 | nM | Ki | J Med Chem (2002) 45: 1853-1859 [PMID:11960497] |
GtoPdb | - | - | 11 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2003) 367: 553-61 [PMID:12764576]; J Pharmacol Exp Ther (1985) 234: 395-401 [PMID:2991499] |
ChEMBL | Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates. | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1998) 41: 4453-4465 [PMID:9804685] |
MT2 receptor/Melatonin receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1946] [GtoPdb: 288] [UniProtKB: P49286] | ||||||||
ChEMBL | Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells | B | 9.66 | pKi | 0.22 | nM | Ki | J Med Chem (2014) 57: 3161-3185 [PMID:24228714] |
ChEMBL | Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells | B | 9.8 | pKi | 0.16 | nM | Ki | J Med Chem (2002) 45: 1853-1859 [PMID:11960497] |
ChEMBL | Compound was tested for binding affinity against human Melatonin receptor type 1B in CHO cells | B | 9.82 | pKi | 0.15 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 2409-2414 |
GtoPdb | - | - | 10.3 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2003) 367: 553-61 [PMID:12764576]; Naunyn Schmiedebergs Arch Pharmacol (1997) 355: 365-75 [PMID:9089668]; J Pharmacol Exp Ther (1998) 285: 1239-45 [PMID:9618428]; J Pharmacol Exp Ther (1985) 234: 395-401 [PMID:2991499] |
Quinone reductase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3959] [UniProtKB: P16083] | ||||||||
ChEMBL | Inhibition of 2-[125I]iodomelatonin binding to Melatonin receptor 3 (MT3) of Syrian hamster brain membrane | B | 8.19 | pKi | 6.5 | nM | Ki | J Med Chem (2002) 45: 1853-1859 [PMID:11960497] |
ChEMBL | Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) incubated at 23 degC by MTT assay | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (2009) 52: 1873-1884 [PMID:19265439] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]