L-serine-O-phosphate [Ligand Id: 1411] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL284377 (Dexfosfoserine, GNF-Pf-1028)
  • mGlu4 receptor/Metabotropic glutamate receptor 4 in Human [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833]
  • mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423]
  • This target only has 0 pki data point
  • 0
1 CHEMBL284377_lig_chart_1 Metabotropic glutamate receptor 4 HumanRat
There should be some charts here, you may need to enable JavaScript!
  • mGlu6 receptor in Human [GtoPdb: 294] [UniProtKB: O15303]
  • mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349]
  • This target only has 0 pki data point
  • 0
2 CHEMBL284377_lig_chart_2 mGlu6 receptor HumanRat
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
3 CHEMBL284377_lig_chart_3 Plasmodium falciparum Plasmodium falciparum
There should be some charts here, you may need to enable JavaScript!
  • mGlu7 receptor in Human [GtoPdb: 295] [UniProtKB: Q14831]
  • This target only has 1 pki data point
  • 4.4
4 CHEMBL284377_lig_chart_4 mGlu7 receptor Human
There should be some charts here, you may need to enable JavaScript!
  • mGlu8 receptor in Human [GtoPdb: 296] [UniProtKB: O00222]
  • This target only has 0 pki data point
  • 0
5 CHEMBL284377_lig_chart_5 mGlu8 receptor Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu4 receptor/Metabotropic glutamate receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833]
ChEMBL Concentration for half maximal activation of metabotropic glutamate mGluR4a in human B 5.89 pEC50 1300 nM EC50 J. Med. Chem. (1995) 38: 1417-1426 [PMID:7738999]
GtoPdb - - 5.9 pEC50 1420 nM EC50 Brain Res Mol Brain Res (1998) 53: 88-97 [PMID:9473604]
ChEMBL Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay B 6 pEC50 1000 nM EC50 Bioorg. Med. Chem. Lett. (2000) 10: 1447-1450 [PMID:10888329]
mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423]
GtoPdb - - 6.2 pIC50 - - - J Neurosci (1993) 13: 1372-8 [PMID:8463825];
Neuropharmacology (1997) 36: 21-30 [PMID:9144638];
Br J Pharmacol (1995) 116: 3279-87 [PMID:8719808];
J Biol Chem (1999) 274: 10008-13 [PMID:10187777];
Neuroreport (1993) 4: 1099-101 [PMID:8106006]
ChEMBL Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active F 4 pEC50 <100000 nM EC50 J. Med. Chem. (2005) 48: 2534-2547 [PMID:15801843]
ChEMBL Concentration for half maximal activation of metabotropic glutamate mGluR4a in rat B 5.4 pEC50 4000 nM EC50 J. Med. Chem. (1995) 38: 1417-1426 [PMID:7738999]
mGlu6 receptor in Human [GtoPdb: 294] [UniProtKB: O15303]
GtoPdb - - 6.4 pEC50 - - - Neuropharmacology (1997) 36: 145-52 [PMID:9144651]
mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349]
ChEMBL Concentration for half maximal activation of metabotropic glutamate mGluR6 in rat B 5.57 pEC50 2700 nM EC50 J. Med. Chem. (1995) 38: 1417-1426 [PMID:7738999]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay F 5.97 pEC50 1080 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay F 5.97 pEC50 >1065 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783]
mGlu7 receptor in Human [GtoPdb: 295] [UniProtKB: Q14831]
GtoPdb - - 4.4 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2000) 362: 546-54 [PMID:11138847]
GtoPdb - - 4.5 pEC50 31000 nM EC50 Brain Res Mol Brain Res (1998) 53: 88-97 [PMID:9473604]
mGlu8 receptor in Human [GtoPdb: 296] [UniProtKB: O00222]
GtoPdb - - 7.2 pIC50 - - - Brain Res Mol Brain Res (1998) 53: 88-97 [PMID:9473604];
Brain Res Mol Brain Res (1999) 67: 201-10 [PMID:10216218]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]