ChEMBL ligand: CHEMBL33567
mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385] There should be some charts here, you may need to enable JavaScript!
mGlu3 receptor/Metabotropic glutamate receptor 3 in Rat [ChEMBL: CHEMBL3067] [GtoPdb: 291] [UniProtKB: P31422] There should be some charts here, you may need to enable JavaScript!
mGlu4 receptor/Metabotropic glutamate receptor 4 in Human [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833] mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423] There should be some charts here, you may need to enable JavaScript!
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] There should be some charts here, you may need to enable JavaScript!
mGlu6 receptor/Metabotropic glutamate receptor 6 in Human [ChEMBL: CHEMBL4573] [GtoPdb: 294] [UniProtKB: O15303] mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349] There should be some charts here, you may need to enable JavaScript!
mGlu8 receptor/Metabotropic glutamate receptor 8 in Human [ChEMBL: CHEMBL3228] [GtoPdb: 296] [UniProtKB: O00222] mGlu8 receptor/Metabotropic glutamate receptor 8 in Mouse [ChEMBL: CHEMBL4626] [GtoPdb: 296] [UniProtKB: P47743] mGlu8 receptor/Metabotropic glutamate receptor 8 in Rat [ChEMBL: CHEMBL2718] [GtoPdb: 296] [UniProtKB: P70579] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385]
ChEMBL	Metabotropic glutamate receptor 1 agonist activity as basal [3H]- IP formation in rat	F	4	pEC50	>100000	nM	EC50	J Med Chem (2004) 47: 456-466 [PMID:14711315]
mGlu3 receptor/Metabotropic glutamate receptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3067] [GtoPdb: 291] [UniProtKB: P31422]
ChEMBL	Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat non neuronal cells	F	4	pEC50	>100000	nM	EC50	J Med Chem (2004) 47: 456-466 [PMID:14711315]
mGlu4 receptor/Metabotropic glutamate receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833]
ChEMBL	Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)	F	6.04	pKi	910	nM	Ki	J Med Chem (2000) 43: 2609-2645 [PMID:10893301]
ChEMBL	Binding affinity at Metabotropic glutamate receptor 4	B	6.33	pKi	470	nM	Ki	J Med Chem (2002) 45: 3171-3183 [PMID:12109902]
ChEMBL	Displacement of [3H]Quisqualate from human mGluR4 receptor expressed in BHK cells	B	6.8	pKi	160	nM	Ki	Bioorg Med Chem (2009) 17: 242-250 [PMID:19042134]
ChEMBL	Agonist activity at mGlu4 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production	F	6.16	pEC50	690	nM	EC50	J Med Chem (2007) 50: 3585-3595 [PMID:17602546]
ChEMBL	Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay	B	6.3	pEC50	500	nM	EC50	Bioorg Med Chem Lett (2000) 10: 1447-1450 [PMID:10888329]
ChEMBL	Activation of human metabotropic glutamate 4 receptor expressed in golden hamster AV12-664 cells	B	6.51	pEC50	310	nM	EC50	J Med Chem (2018) 61: 10040-10052 [PMID:30365309]
ChEMBL	Concentration for half maximal activation of metabotropic glutamate mGluR4a in human	B	6.7	pEC50	200	nM	EC50	J Med Chem (1995) 38: 1417-1426 [PMID:7738999]
ChEMBL	Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium accumulation by Fluo-4 AM dye based fluorescence assay	F	6.89	pEC50	130	nM	EC50	J Med Chem (2018) 61: 1969-1989 [PMID:29397723]
ChEMBL	Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulation after 30 mins by scintillation and luminescence counting method	F	7	pEC50	100	nM	EC50	J Med Chem (2018) 61: 1969-1989 [PMID:29397723]
mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423]
GtoPdb	-	-	6.3	pKd	-	-	-	J Biol Chem (1999) 274: 10008-13 [PMID:10187777]
ChEMBL	Displacement of [3H]L-AP4 from rat mGluR4 expressed in BHK cells	B	6.8	pKi	160	nM	Ki	Bioorg Med Chem Lett (2006) 16: 196-199 [PMID:16213710]
ChEMBL	Displacement of [3H]L-AP4 from rat recombinant mGluR4 expressed in BHK cells by SPA assay	B	6.8	pKi	160	nM	Ki	Bioorg Med Chem (2007) 15: 3161-3170 [PMID:17350267]
ChEMBL	Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active	F	4	pEC50	<100000	nM	EC50	J Med Chem (2005) 48: 2534-2547 [PMID:15801843]
ChEMBL	Concentration for half maximal activation of metabotropic glutamate mGluR4a in rat	B	5.92	pEC50	1200	nM	EC50	J Med Chem (1995) 38: 1417-1426 [PMID:7738999]
ChEMBL	Effect on Metabotropic glutamate receptor 4	B	6.04	pEC50	910	nM	EC50	J Med Chem (1997) 40: 3700-3705 [PMID:9357538]
ChEMBL	Functional activity at rat mGluR4	F	6.29	pEC50	510	nM	EC50	Bioorg Med Chem Lett (2006) 16: 196-199 [PMID:16213710]
ChEMBL	Agonist activity at rat recombinant mGluR4 expressed in BHK cells	F	6.29	pEC50	510	nM	EC50	Bioorg Med Chem (2007) 15: 3161-3170 [PMID:17350267]
ChEMBL	Concentration for half maximal activation of metabotropic glutamate mGluR4a in rat	B	6.3	pEC50	500	nM	EC50	J Med Chem (1995) 38: 1417-1426 [PMID:7738999]
ChEMBL	Stimulation od [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells	F	6.49	pEC50	320	nM	EC50	J Med Chem (2005) 48: 2534-2547 [PMID:15801843]
ChEMBL	Metabotropic glutamate receptor 4 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells	F	6.49	pEC50	320	nM	EC50	J Med Chem (2004) 47: 456-466 [PMID:14711315]
ChEMBL	Effective concentration against Metabotropic glutamate receptor 4	B	6.7	pEC50	200	nM	EC50	J Med Chem (2005) 48: 2534-2547 [PMID:15801843]
ChEMBL	Agonist activity at rat mGlu4 receptor expressed in HEK293 cells coexpressing Gq/Gi and EAAC1 assessed as intracellular calcium production measured every 1.5 secs for 60 secs by Fluo-4-AM based fluorometry	F	6.89	pEC50	130	nM	EC50	Bioorg Med Chem (2012) 20: 4716-4726 [PMID:22750138]
ChEMBL	Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader	F	6.89	pEC50	130	nM	EC50	J Med Chem (2010) 53: 2797-2813 [PMID:20218620]
ChEMBL	Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular inositol phosphate accumulation after 1 hr by scintillation counting	F	7.02	pEC50	96	nM	EC50	J Med Chem (2010) 53: 2797-2813 [PMID:20218620]
ChEMBL	Agonist activity at rat mGluR4 receptor expressed HEK293 cells assessed as effect on inositol phosphate production	F	7.1	pEC50	80	nM	EC50	J Med Chem (2007) 50: 4656-4664 [PMID:17722902]
ChEMBL	Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay	F	7.52	pEC50	30	nM	EC50	Bioorg Med Chem Lett (2015) 25: 2523-2526 [PMID:25958247]
ChEMBL	Agonist activity at rat mGlu4 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay	F	7.52	pEC50	30	nM	EC50	J Med Chem (2016) 59: 914-924 [PMID:26814576]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
ChEMBL	Metabotropic glutamate receptor 5 agonist activity as basal [3H]- IP formation in rat	F	4	pEC50	>100000	nM	EC50	J Med Chem (2004) 47: 456-466 [PMID:14711315]
mGlu6 receptor/Metabotropic glutamate receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4573] [GtoPdb: 294] [UniProtKB: O15303]
ChEMBL	Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).	F	6.05	pKi	900	nM	Ki	J Med Chem (2000) 43: 2609-2645 [PMID:10893301]
ChEMBL	Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulation after 30 mins by scintillation and luminescence counting method	F	5.62	pEC50	2400	nM	EC50	J Med Chem (2018) 61: 1969-1989 [PMID:29397723]
ChEMBL	Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium accumulation by Fluo-4 AM dye based fluorescence assay	F	6	pEC50	1000	nM	EC50	J Med Chem (2018) 61: 1969-1989 [PMID:29397723]
ChEMBL	Activation of human metabotropic glutamate 6 receptor expressed in golden hamster AV12-664 cells	B	7.26	pEC50	55	nM	EC50	J Med Chem (2018) 61: 10040-10052 [PMID:30365309]
mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349]
ChEMBL	Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay	F	5.46	pEC50	3450	nM	EC50	Bioorg Med Chem Lett (2015) 25: 2523-2526 [PMID:25958247]
ChEMBL	Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular inositol phosphate accumulation after 1 hr by scintillation counting	F	5.48	pEC50	3300	nM	EC50	J Med Chem (2010) 53: 2797-2813 [PMID:20218620]
ChEMBL	Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate production	F	5.68	pEC50	2080	nM	EC50	J Med Chem (2007) 50: 4656-4664 [PMID:17722902]
ChEMBL	Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay	F	5.72	pEC50	1910	nM	EC50	J Med Chem (2016) 59: 914-924 [PMID:26814576]
ChEMBL	Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader	F	6	pEC50	1000	nM	EC50	J Med Chem (2010) 53: 2797-2813 [PMID:20218620]
ChEMBL	Concentration for half maximal activation of metabotropic glutamate mGluR6 in rat	B	6.05	pEC50	900	nM	EC50	J Med Chem (1995) 38: 1417-1426 [PMID:7738999]
ChEMBL	Effect on Metabotropic glutamate receptor 6	B	6.24	pEC50	570	nM	EC50	J Med Chem (1997) 40: 3700-3705 [PMID:9357538]
ChEMBL	Activity at rat recombinant mGluR6 expressed in CHO cells assessed as cAMP production	F	6.47	pEC50	340	nM	EC50	Bioorg Med Chem (2007) 15: 3161-3170 [PMID:17350267]
ChEMBL	Activity at rat mGluR6 by measuring cAMP formation in CHO cells	F	6.47	pEC50	340	nM	EC50	Bioorg Med Chem Lett (2006) 16: 196-199 [PMID:16213710]
ChEMBL	Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells	F	7.26	pEC50	55	nM	EC50	J Med Chem (2004) 47: 456-466 [PMID:14711315]
mGlu8 receptor/Metabotropic glutamate receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3228] [GtoPdb: 296] [UniProtKB: O00222]
GtoPdb	-	-	6.7	pKd	-	-	-	Brain Res Mol Brain Res (1999) 67: 201-10 [PMID:10216218]
ChEMBL	Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).	F	7.21	pKi	61	nM	Ki	J Med Chem (2000) 43: 2609-2645 [PMID:10893301]
ChEMBL	Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production	F	6.25	pEC50	560	nM	EC50	J Med Chem (2007) 50: 3585-3595 [PMID:17602546]
ChEMBL	Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulation after 30 mins by scintillation and luminescence counting method	F	6.54	pEC50	290	nM	EC50	J Med Chem (2018) 61: 1969-1989 [PMID:29397723]
ChEMBL	Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium accumulation by Fluo-4 AM dye based fluorescence assay	F	6.54	pEC50	290	nM	EC50	J Med Chem (2018) 61: 1969-1989 [PMID:29397723]
ChEMBL	Activation of human metabotropic glutamate 8 receptor expressed in golden hamster AV12-664 cells	B	7.22	pEC50	60	nM	EC50	J Med Chem (2018) 61: 10040-10052 [PMID:30365309]
mGlu8 receptor/Metabotropic glutamate receptor 8 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4626] [GtoPdb: 296] [UniProtKB: P47743]
ChEMBL	Concentration for half maximal activation of metabotropic glutamate mGluR8 in mouse	B	6.4	pEC50	400	nM	EC50	J Med Chem (1995) 38: 1417-1426 [PMID:7738999]
mGlu8 receptor/Metabotropic glutamate receptor 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2718] [GtoPdb: 296] [UniProtKB: P70579]
ChEMBL	Displacement of [3H]LY341495 from rat mGluR8 expressed in BHK cells	B	5.72	pKi	1900	nM	Ki	Bioorg Med Chem Lett (2006) 16: 196-199 [PMID:16213710]
ChEMBL	Displacement of [3H]LY341495 from rat recombinant mGluR8 expressed in BHK cells by SPA assay	B	5.72	pKi	1900	nM	Ki	Bioorg Med Chem (2007) 15: 3161-3170 [PMID:17350267]
ChEMBL	Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader	F	6.52	pEC50	300	nM	EC50	J Med Chem (2010) 53: 2797-2813 [PMID:20218620]
ChEMBL	Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular inositol phosphate accumulation after 1 hr by scintillation counting	F	6.62	pEC50	240	nM	EC50	J Med Chem (2010) 53: 2797-2813 [PMID:20218620]
ChEMBL	Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate production	F	6.89	pEC50	128	nM	EC50	J Med Chem (2007) 50: 4656-4664 [PMID:17722902]
ChEMBL	Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay	F	6.96	pEC50	110	nM	EC50	Bioorg Med Chem Lett (2015) 25: 2523-2526 [PMID:25958247]
ChEMBL	Agonist activity at rat mGlu8 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay	F	7.15	pEC50	70	nM	EC50	J Med Chem (2016) 59: 914-924 [PMID:26814576]
ChEMBL	Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat non neuronal cells	F	7.22	pEC50	60	nM	EC50	J Med Chem (2004) 47: 456-466 [PMID:14711315]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]