MPPG [Ligand Id: 1415] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL86508
  • mGlu2 receptor/Metabotropic glutamate receptor 2 in Human [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416]
  • This target only has 1 pki data point
  • 4.96
1 CHEMBL86508_lig_chart_1 Metabotropic glutamate receptor 2 Human
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  • mGlu4 receptor in Rat [GtoPdb: 292] [UniProtKB: P31423]
  • This target only has 1 pki data point
  • 4.2
2 CHEMBL86508_lig_chart_2 mGlu4 receptor Rat
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  • mGlu6 receptor in Human [GtoPdb: 294] [UniProtKB: O15303]
  • This target only has 0 pki data point
  • 0
3 CHEMBL86508_lig_chart_3 mGlu6 receptor Human
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  • mGlu7 receptor in Human [GtoPdb: 295] [UniProtKB: Q14831]
  • This target only has 1 pki data point
  • 3.8
4 CHEMBL86508_lig_chart_4 mGlu7 receptor Human
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  • mGlu8 receptor in Human [GtoPdb: 296] [UniProtKB: O00222]
  • This target only has 0 pki data point
  • 0
5 CHEMBL86508_lig_chart_5 mGlu8 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416]
ChEMBL Antagonist potency against cloned Metabotropic glutamate receptor 2 F 4.96 pKi 11000 nM Ki J. Med. Chem. (2000) 43: 2609-2645 [PMID:10893301]
mGlu4 receptor in Rat [GtoPdb: 292] [UniProtKB: P31423]
GtoPdb - - 4.2 pKi - - - J Biol Chem (1999) 274: 10008-13 [PMID:10187777]
mGlu6 receptor in Human [GtoPdb: 294] [UniProtKB: O15303]
GtoPdb - - 3.3 pIC50 - - - Bioorg Med Chem Lett (1997) 7: 1195-1198
mGlu7 receptor in Human [GtoPdb: 295] [UniProtKB: Q14831]
GtoPdb - - 3.8 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2000) 362: 546-54 [PMID:11138847]
mGlu8 receptor in Human [GtoPdb: 296] [UniProtKB: O00222]
GtoPdb - - 4.33 pIC50 46500 nM IC50 Brain Res Mol Brain Res (1998) 53: 88-97 [PMID:9473604]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]