MPPG [Ligand Id: 1415] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL86508 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416] | ||||||||
| ChEMBL | Antagonist potency against cloned Metabotropic glutamate receptor 2 | F | 4.96 | pKi | 11000 | nM | Ki | J Med Chem (2000) 43: 2609-2645 [PMID:10893301] |
| mGlu4 receptor in Rat [GtoPdb: 292] [UniProtKB: P31423] | ||||||||
| GtoPdb | - | - | 4.2 | pKi | - | - | - | J Biol Chem (1999) 274: 10008-13 [PMID:10187777] |
| mGlu6 receptor in Human [GtoPdb: 294] [UniProtKB: O15303] | ||||||||
| GtoPdb | - | - | 3.3 | pIC50 | - | - | - | Bioorg Med Chem Lett (1997) 7: 1195-1198 |
| mGlu7 receptor in Human [GtoPdb: 295] [UniProtKB: Q14831] | ||||||||
| GtoPdb | - | - | 3.8 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2000) 362: 546-54 [PMID:11138847] |
| mGlu8 receptor in Human [GtoPdb: 296] [UniProtKB: O00222] | ||||||||
| GtoPdb | - | - | 4.33 | pIC50 | 46500 | nM | IC50 | Brain Res Mol Brain Res (1998) 53: 88-97 [PMID:9473604] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
